Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts

Agnieszka Brojakowska; Anupreet Kour; Mark Charles Thel; Eunbee Park; Malik Bisserier; Venkata Naga Srikanth Garikipati; Lahouaria Hadri; Paul J. Mills; Kenneth Walsh; David A. Goukassian

doi:10.1038/s42003-022-03777-z

Communications Biology (Aug 2022)

Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts

Agnieszka Brojakowska,
Anupreet Kour,
Mark Charles Thel,
Eunbee Park,
Malik Bisserier,
Venkata Naga Srikanth Garikipati,
Lahouaria Hadri,
Paul J. Mills,
Kenneth Walsh,
David A. Goukassian

Affiliations

Agnieszka Brojakowska: Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai
Anupreet Kour: Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine
Mark Charles Thel: Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine
Eunbee Park: Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine
Malik Bisserier: Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai
Venkata Naga Srikanth Garikipati: Dorothy M. Davis Heart Lung and Research Institute and Department of Emergency Medicine, The Ohio State University Wexner Medical Center
Lahouaria Hadri: Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai
Paul J. Mills: Center of Excellence for Research and Training in Integrative Health, University of California San Diego
Kenneth Walsh: Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine
David A. Goukassian: Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s42003-022-03777-z
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 6

Abstract

Read online

Deep targeted DNA sequencing of peripheral blood mononuclear cells isolated from blood samples from 14 astronauts who flew Shuttle missions between 1998–2001 identifies 34 non-silent mutations, predominantly in TP53 and DNMT3A.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal