Frontiers in Neurology (Jan 2022)

Avenir® vs. AxiumTM Coils for the Treatment of Intracranial Aneurysms: Results of a Multicenter Randomized Controlled Trial With Short-Term Follow-Up

  • Wei Li,
  • Wei Li,
  • Ming Ye,
  • Alexandru Cimpoca,
  • Hans Henkes,
  • Hans Henkes,
  • Honglei Wang,
  • Xiang Xu,
  • Yuxiang Gu,
  • Huaizhang Shi,
  • Hongming Ji,
  • Feng Wang,
  • Yuanli Zhao,
  • Geng Guo,
  • Hongqi Zhang,
  • Youxiang Li,
  • Youxiang Li

DOI
https://doi.org/10.3389/fneur.2021.817989
Journal volume & issue
Vol. 12

Abstract

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PurposeEndovascular coil occlusion is a successful and rapidly evolving strategy used to treat patients who present with intracranial aneurysms. This study aimed to compare the safety and efficacy of the Avenir® and AxiumTM passive mechanically detachable coil systems.MethodsA prospective, multicenter, randomized controlled study was carried out at ten medical centers from March 2018 to December 2019. A series of consecutive patients diagnosed with intracranial aneurysms were randomly assigned to undergo endovascular treatment with either the Avenir® or the AxiumTM mechanically detachable coil systems. The short-term outcomes from the two groups were compared with a focus on treatment efficacy and safety.ResultsA total of 162 and 161 patients were enrolled in the Avenir and Axium groups, respectively. The rate of successful coil detachment was 100% for the Avenir group and 99.38% for the Axium group. At the six-month follow-up visit, the overall aneurysm occlusion rate was 94.66% for the Avenir group and 96.95% for the Axium group (p > 0.05). We observed no statistically significant differences in clinical condition (as per the modified Rankin Scale) or the degree of aneurysm occlusion (as determined by digital subtraction angiography [DSA] and Raymond-Roy Occlusion Classification). Surgical complications were reported in 27 subjects in the Avenir group and 22 in the Axium group (p > 0.05). DSA performed at 6 months revealed complete aneurysm occlusion in 84 and 86% of patients in the Avenir and Axium groups, respectively.ConclusionWe observed no significant short-term differences with respect to efficacy or safety when using either Avenir® or AxiumTM coils for the treatment of intracranial aneurysms.

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