Molecules (Jul 2023)

Ni(II)-Salophen—Comprehensive Analysis on Electrochemical and Spectral Characterization and Biological Studies

  • Francis Aurelien Ngounoue Kamga,
  • Madalina-Marina Hrubaru,
  • Oana Enache,
  • Elena Diacu,
  • Constantin Draghici,
  • Victorita Tecuceanu,
  • Eleonora-Mihaela Ungureanu,
  • Stephanie Nkemone,
  • Peter T. Ndifon

DOI
https://doi.org/10.3390/molecules28145464
Journal volume & issue
Vol. 28, no. 14
p. 5464

Abstract

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New aspects of the Ni(II)-salophen complex and salophen ligand precursor were found during deep electrochemical and optical characterization, as well as biological studies for new pharmacological applications. Physicochemical and spectroscopic methods (1H- and 13C-NMR, FT-IR and UV-Vis, electrospray ionization mass spectroscopy, thermogravimetric analysis, and molar conductance measurements) were also used to prove that the salophen ligand acts as a tetradentate and coordinates to the central metal through nitrogen and oxygen atoms. The electrochemical behavior of the free Schiff salophen ligand (H2L) and its Ni(II) complex (Ni(II)L) was deeply studied in tetrabutylammonium perchlorate solutions in acetonitrile via CV, DPV, and RDE. Blue films on the surfaces of the electrodes as a result of the electropolymerization processes were put in evidence and characterized via CV and DPV. (H2L) and Ni(II)L complexes were tested for their antimicrobial, antifungal, and antioxidant activity, showing good antimicrobial and antifungal activity against several bacteria and fungi.

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