Biological function and research progress of N6-methyladenosine binding protein heterogeneous nuclear ribonucleoprotein A2B1 in human cancers

Yue Wu; Yue Wu; Yue Wu; An Li; An Li; An Li; Can Chen; Can Chen; Can Chen; Zhang Fang; Zhang Fang; Zhang Fang; Lujun Chen; Lujun Chen; Lujun Chen; Xiao Zheng; Xiao Zheng; Xiao Zheng

doi:10.3389/fonc.2023.1229168

Frontiers in Oncology (Jul 2023)

Biological function and research progress of N6-methyladenosine binding protein heterogeneous nuclear ribonucleoprotein A2B1 in human cancers

Yue Wu,
Yue Wu,
Yue Wu,
An Li,
An Li,
An Li,
Can Chen,
Can Chen,
Can Chen,
Zhang Fang,
Zhang Fang,
Zhang Fang,
Lujun Chen,
Lujun Chen,
Lujun Chen,
Xiao Zheng,
Xiao Zheng,
Xiao Zheng

Affiliations

Yue Wu: Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China
Yue Wu: Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China
Yue Wu: Institute for Cell Therapy, Soochow University, Changzhou, Jiangsu, China
An Li: Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China
An Li: Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China
An Li: Institute for Cell Therapy, Soochow University, Changzhou, Jiangsu, China
Can Chen: Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China
Can Chen: Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China
Can Chen: Institute for Cell Therapy, Soochow University, Changzhou, Jiangsu, China
Zhang Fang: Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China
Zhang Fang: Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China
Zhang Fang: Institute for Cell Therapy, Soochow University, Changzhou, Jiangsu, China
Lujun Chen: Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China
Lujun Chen: Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China
Lujun Chen: Institute for Cell Therapy, Soochow University, Changzhou, Jiangsu, China
Xiao Zheng: Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China
Xiao Zheng: Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China
Xiao Zheng: Institute for Cell Therapy, Soochow University, Changzhou, Jiangsu, China

DOI: https://doi.org/10.3389/fonc.2023.1229168
Journal volume & issue: Vol. 13

Abstract

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N6-methyladenosine (m6A) is the most prevalent internal modification found in both mRNA and lncRNA. It exerts reversible regulation over RNA function and affects RNA processing and metabolism in various diseases, especially tumors. The m6A binding protein, hnRNPA2B1, is extensively studied as a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) protein family. It is frequently dysregulated and holds significant importance in multiple types of tumors. By recognizing m6A sites for variable splicing, maintaining RNA stability, and regulating translation and transport, hnRNPA2B1 plays a vital role in various aspects of tumor development, metabolism, and regulation of the immune microenvironment. In this review, we summarized the latest research on the functional roles and underlying molecular mechanisms of hnRNPA2B1. Moreover, we discussed its potential as a target for tumor therapy.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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