Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma

Daisuke Murayama; Soji Toda; Yoichiro Okubo; Hiroyuki Hayashi; Ai Matsui; Mio Yasukawa; Hiroyuki Iwasaki

doi:10.1155/2021/3024639

Case Reports in Endocrinology (Jan 2021)

Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma

Daisuke Murayama,
Soji Toda,
Yoichiro Okubo,
Hiroyuki Hayashi,
Ai Matsui,
Mio Yasukawa,
Hiroyuki Iwasaki

Affiliations

Daisuke Murayama: Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa 241-8515, Japan
Soji Toda: Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa 241-8515, Japan
Yoichiro Okubo: Department of Pathology, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa 241-8515, Japan
Hiroyuki Hayashi: Department of Pathology, Yokohama Municipal Citizen’s Hospital, 1-1 Mitsuzawanishicho Kanagawa-ku, Yokohama, Kanagawa 221-0855, Japan
Ai Matsui: Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa 241-8515, Japan
Mio Yasukawa: Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa 241-8515, Japan
Hiroyuki Iwasaki: Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa 241-8515, Japan

DOI: https://doi.org/10.1155/2021/3024639
Journal volume & issue: Vol. 2021

Abstract

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Thyroid-associated ophthalmopathy (TAO) is an inflammation of the extraocular muscles and periorbital connective tissue caused by autoantibodies against common antigens to both the thyroid and orbit. The release of antigens and induction of hypothyroidism caused by radioactive iodine (RAI) therapy may exacerbate TAO. Here, we present the case of a 67-year-old-woman treated with RAI therapy for metastatic follicular thyroid carcinoma who presented with TAO during the course of sorafenib administration. Tg and TgAb levels were gradually decreased with sorafenib and lenvatinib treatment, and TAO was improved without any ophthalmologic treatment.

Published in Case Reports in Endocrinology

ISSN: 2090-6501 (Print); 2090-651X (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://onlinelibrary.wiley.com/journal/7520

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