Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Charlotte L. Scott; Fang Zheng; Patrick De Baetselier; Liesbet Martens; Yvan Saeys; Sofie De Prijck; Saskia Lippens; Chloé Abels; Steve Schoonooghe; Geert Raes; Nick Devoogdt; Bart N. Lambrecht; Alain Beschin; Martin Guilliams

doi:10.1038/ncomms10321

Nature Communications (Jan 2016)

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Charlotte L. Scott,
Fang Zheng,
Patrick De Baetselier,
Liesbet Martens,
Yvan Saeys,
Sofie De Prijck,
Saskia Lippens,
Chloé Abels,
Steve Schoonooghe,
Geert Raes,
Nick Devoogdt,
Bart N. Lambrecht,
Alain Beschin,
Martin Guilliams

Affiliations

Charlotte L. Scott: Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center
Fang Zheng: Myeloid Cell Immunology, VIB
Patrick De Baetselier: Myeloid Cell Immunology, VIB
Liesbet Martens: Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center
Yvan Saeys: Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center
Sofie De Prijck: Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center
Saskia Lippens: Department of Biomedical Molecular Biology, Ghent University
Chloé Abels: Myeloid Cell Immunology, VIB
Steve Schoonooghe: Myeloid Cell Immunology, VIB
Geert Raes: Myeloid Cell Immunology, VIB
Nick Devoogdt: Cellular and Molecular Immunology Research Group, Vrije Universiteit Brussel
Bart N. Lambrecht: Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center
Alain Beschin: Myeloid Cell Immunology, VIB
Martin Guilliams: Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center

DOI: https://doi.org/10.1038/ncomms10321
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

Read online

Tissue-resident macrophages are mostly derived from embryonic progenitors. Scott et al. develop a mouse model to specifically deplete Kupffer cells (KC) in vivoand show that monocyte-derived cells can repopulate KC niche and behave similar to their embryonically-derived counterparts.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal