Repression of RNA polymerase by the archaeo-viral regulator ORF145/RIP

Carol Sheppard; Fabian Blombach; Adam Belsom; Sarah Schulz; Tina Daviter; Katherine Smollett; Emilie Mahieu; Susanne Erdmann; Philip Tinnefeld; Roger Garrett; Dina Grohmann; Juri Rappsilber; Finn Werner

doi:10.1038/ncomms13595

Nature Communications (Nov 2016)

Repression of RNA polymerase by the archaeo-viral regulator ORF145/RIP

Carol Sheppard,
Fabian Blombach,
Adam Belsom,
Sarah Schulz,
Tina Daviter,
Katherine Smollett,
Emilie Mahieu,
Susanne Erdmann,
Philip Tinnefeld,
Roger Garrett,
Dina Grohmann,
Juri Rappsilber,
Finn Werner

Affiliations

Carol Sheppard: Division of Biosciences, Institute of Structural and Molecular Biology, University College London
Fabian Blombach: Division of Biosciences, Institute of Structural and Molecular Biology, University College London
Adam Belsom: Wellcome Trust Centre for Cell Biology, University of Edinburgh
Sarah Schulz: Physikalische und Theoretische Chemie—NanoBioSciences, Technische Universität Braunschweig
Tina Daviter: Division of Biosciences, Institute of Structural and Molecular Biology, University College London
Katherine Smollett: Division of Biosciences, Institute of Structural and Molecular Biology, University College London
Emilie Mahieu: Division of Biosciences, Institute of Structural and Molecular Biology, University College London
Susanne Erdmann: Department of Biology, University of Copenhagen
Philip Tinnefeld: Physikalische und Theoretische Chemie—NanoBioSciences, Technische Universität Braunschweig
Roger Garrett: Department of Biology, University of Copenhagen
Dina Grohmann: Physikalische und Theoretische Chemie—NanoBioSciences, Technische Universität Braunschweig
Juri Rappsilber: Wellcome Trust Centre for Cell Biology, University of Edinburgh
Finn Werner: Division of Biosciences, Institute of Structural and Molecular Biology, University College London

DOI: https://doi.org/10.1038/ncomms13595
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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How archaeal viruses perturb host transcription machinery is poorly understood. Here, the authors provide evidence that the archaeo-viral transcription factor ORF145/RIP targets host RNA polymerase, repressing its activity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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