Nature Communications (Apr 2018)
Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons
- Rahul Dhandapani,
- Cynthia Mary Arokiaraj,
- Francisco J. Taberner,
- Paola Pacifico,
- Sruthi Raja,
- Linda Nocchi,
- Carla Portulano,
- Federica Franciosa,
- Mariano Maffei,
- Ahmad Fawzi Hussain,
- Fernanda de Castro Reis,
- Luc Reymond,
- Emerald Perlas,
- Simone Garcovich,
- Stefan Barth,
- Kai Johnsson,
- Stefan G. Lechner,
- Paul A. Heppenstall
Affiliations
- Rahul Dhandapani
- Epigenetics and Neurobiology Unit, EMBL Rome
- Cynthia Mary Arokiaraj
- Epigenetics and Neurobiology Unit, EMBL Rome
- Francisco J. Taberner
- Institute of Pharmacology, Heidelberg University
- Paola Pacifico
- Epigenetics and Neurobiology Unit, EMBL Rome
- Sruthi Raja
- Epigenetics and Neurobiology Unit, EMBL Rome
- Linda Nocchi
- Epigenetics and Neurobiology Unit, EMBL Rome
- Carla Portulano
- Epigenetics and Neurobiology Unit, EMBL Rome
- Federica Franciosa
- Epigenetics and Neurobiology Unit, EMBL Rome
- Mariano Maffei
- Epigenetics and Neurobiology Unit, EMBL Rome
- Ahmad Fawzi Hussain
- Department of Gynecology and Obstetrics, University Hospital RWTH Aachen
- Fernanda de Castro Reis
- Epigenetics and Neurobiology Unit, EMBL Rome
- Luc Reymond
- Ecole Polytechnique Federale de Lausanne, Institute of Chemical Sciences and Engineering (ISIC), Institute of Bioengineering, National Centre of Competence in Research (NCCR) in Chemical Biology
- Emerald Perlas
- Epigenetics and Neurobiology Unit, EMBL Rome
- Simone Garcovich
- Institute of Dermatology, Catholic University of the Sacred Heart
- Stefan Barth
- South African Research Chair in Cancer Biotechnology, Institute of Infectious Disease and Molecular Medicine (IDM), Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town
- Kai Johnsson
- Department of Chemical Biology, Max-Planck Institute for Medical Research
- Stefan G. Lechner
- Institute of Pharmacology, Heidelberg University
- Paul A. Heppenstall
- Epigenetics and Neurobiology Unit, EMBL Rome
- DOI
- https://doi.org/10.1038/s41467-018-04049-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
There are several classes of sensory neuron that contribute to pain states. Here, the authors demonstrate that TrkB+ sensory neurons detect light touch under normal conditions in mice but contribute to hypersensitivity in models of chronic pain, and that ligand-guided laser ablation of TrkB+ sensory neurons in the mouse skin attenuates this hypersensitivity.
