The effect of aloin in blood glucose and antioxidants in male albino rats with Streptozoticin-induced diabetic

Abstract

The anti-diabetic effect of aloin was examined in vivo in the current study, similar to the study, which for four weeks examined how aloin affected the blood sugar, insulin, and antioxidant levels in both healthy and diabetic rats generated by streptozotocin. Adult male albino rats were experimentally given a single intraperitoneal injection of 60 mg/kg of streptozotocin to induced diabetes. The in vitro experiment utilized blood samples, and adult male albino rats' kidneys, pancreas and liver were separated. In comparison to control diabetic rats, aloin isolates (30 mg / kg) body weight for 30 days considerably decreased serum glucose and effectively boosted serum insulin levels. Liver and kidney congeners of malondialdehyde (MDA) were substantially decreased while, Catalase (CAT), superoxide dismutase (SOD) and Congeners Glutathione (GSH) were significantly boosted as contrasted to diabetic rats after aloin therapy. Moreover, a histological assessment of the pancreas was performed.These results show the promise of aloin at a dose of 30 mg/kg body weight for 30 days as an antidiabetic and antioxidant agent.

Keywords

• Diabetes mellitus (DM)
• Aloe vera L.
• Liliaceae
• Aloin
• Glutathione (GSH)
• Malondialdehyde (MDA)