Clinical diagnostics role of serum Chlamydia pneumoniae antibodies and acute phase proteins in acute coronary syndrome

Abstract

The study was aimed at identifying clinical diagnostics role of Chlamydia pneumoniae antibodies (ATCP), IgA, G, M, and acute phase proteins in acute coronary syndrome (ACS). In 91 hospitalized ACS patients, aged 35-70 years (mean age 54, 74+0, 89 years), serum levels of specific ATCP IgM, IgA, IgG, C-reactive protein (CRP), and fibrinogen (F) were measured at Days 1, 14, and 27. The participants were divided into two groups: with or without ST segment elevation (ACS ST 1 and ACS STO, respectively). Specific ATCP titers were measured by immuno-enzyme method (test systems SeroCP™IgG, IgA, IgM EIISA, Savyon, Israel). In ACS ST 1 group, ATCP IgM titers, CRP (5, 6 mg/l) and F (4, 7 mg/l) levels were increased, ACS clinical course was more severe, with myocardial infarction (MI) development in 100 % patients; complications were more common. In ACS STO group, no signs of active CP infection were observed; CRP (2, 5 mg/l) and F (3, 7 g/l) level increase was less prominent; MI developed in 50 %. ATCP, CRP, and F level measurement in ACS facilitated differential diagnostics, as well as complication and outcome prognosis.

Keywords

• acute coronary syndrome
• atherosclerosis
• coronary heart disease
• chlamydia pneumoniae antibodies
• cfreactive protein
• fibrinogen