Hypervirulent Klebsiella pneumoniae infection in a woman with a CDH1 gene mutation

Abstract

The CDH1 gene, which encodes E-cadherin, may be associated with cancer when mutated, but the significance of mutations in the context of infection is unknown. In this report, we describe a case of disseminated hypervirulent Klebsiella pneumoniae infection in a 49 year old Caucasian woman with a documented CDH1 mutation.

Keywords

• Uveitis
• Suppurative
• Cadherin-1
• Disease susceptibility
• Host-pathogen interactions
• Klebsiella pneumoniae/pathogenicity