786 Dose selection for DuoBody®-PD-L1×4-1BB (GEN1046) using a semimechanistic pharmacokinetics/pharmacodynamics model that leverages preclinical and clinical data

• Manish Gupta,
• Maria Jure-Kunkel,
• Alexander Muik,
• Özlem Türeci,
• Tahamtan Ahmadi,
• Ugur Sahin,
• Ulf Forssmann,
• Marc Presler,
• Eleni Lagkadinou,
• Gaurav Bajaj,
• Fereshteh Nazari,
• Craig Thalhauser

Affiliations

Manish Gupta

ENT, Maharishi Markandeshwar University, Mullana, Haryana, India

Maria Jure-Kunkel

2Genmab A/S, Utrecht, Netherlands

Alexander Muik

1BioNTech SE, Mainz, Germany

Özlem Türeci

1BioNTech SE, Mainz, Germany

Tahamtan Ahmadi

2Genmab A/S, Utrecht, Netherlands

Ugur Sahin

1BioNTech SE, Mainz, Germany

Ulf Forssmann

8Genmab A/S, Princeton, NJ, USA

Marc Presler

1Applied BioMath, LLC, Concord, MA, USA

Eleni Lagkadinou

6BioNTech SE, Mainz, Germany

Gaurav Bajaj

7Genmab, Princeton, NJ, USA

Fereshteh Nazari

2Applied Biomath LLC, Concord, MA, United States

Craig Thalhauser

1Genmab US, Princeton, NJ, United States