Research progress of programmed cell death protein-1 gene polymorphism and its role in hepatocellular carcinoma

Abstract

In recent years it has been found that programmed cell death protein-1 (PD-1) gene polymorphism is associated with susceptibility, clinical phenotype and prognosis of many diseases, especially malignant tumors. The study of PD-1 gene polymorphism is expected to provide new ideas for susceptibility analysis and immunotherapy of some malignant tumors. In this paper, we preliminarily summarize that TT genotype of rs2297136, GG genotype of rs4143815, CC genotype of rs36084323, AA genotype of rs10204525 and GG genotype of rs36084323 are associated with the susceptibility of hepatocellular carcinoma (HCC) through literature review. The relationship between PD-1 gene single nucleotide polymorphism (SNP) and HCC deserves further investigation.

Keywords

• programmed cell death protein-1
• single nucleotide polymorphism
• hepatocellular carcinoma
• susceptibility
• immunotherapy