Hyper-CEST NMR of metal organic polyhedral cages reveals hidden diastereomers with diverse guest exchange kinetics

Jabadurai Jayapaul; Sanna Komulainen; Vladimir V. Zhivonitko; Jiří Mareš; Chandan Giri; Kari Rissanen; Perttu Lantto; Ville-Veikko Telkki; Leif Schröder

doi:10.1038/s41467-022-29249-w

Nature Communications (Mar 2022)

Hyper-CEST NMR of metal organic polyhedral cages reveals hidden diastereomers with diverse guest exchange kinetics

Jabadurai Jayapaul,
Sanna Komulainen,
Vladimir V. Zhivonitko,
Jiří Mareš,
Chandan Giri,
Kari Rissanen,
Perttu Lantto,
Ville-Veikko Telkki,
Leif Schröder

Affiliations

Jabadurai Jayapaul: Molecular Imaging, Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
Sanna Komulainen: NMR Research Unit, University of Oulu
Vladimir V. Zhivonitko: NMR Research Unit, University of Oulu
Jiří Mareš: NMR Research Unit, University of Oulu
Chandan Giri: University of Jyvaskyla, Department of Chemistry
Kari Rissanen: University of Jyvaskyla, Department of Chemistry
Perttu Lantto: NMR Research Unit, University of Oulu
Ville-Veikko Telkki: NMR Research Unit, University of Oulu
Leif Schröder: Molecular Imaging, Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)

DOI: https://doi.org/10.1038/s41467-022-29249-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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Self-assembling nanostructures that trap guest molecules find applications in materials research and the life sciences. Here, authors describe how ultra-sensitive NMR reveals sub-types with broken symmetry that significantly impacts guest exchange.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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