A single-cell transcriptional atlas reveals resident progenitor cell niche functions in TMJ disc development and injury

Ruiye Bi; Qing Yin; Haohan Li; Xianni Yang; Yiru Wang; Qianli Li; Han Fang; Peiran Li; Ping Lyu; Yi Fan; Binbin Ying; Songsong Zhu

doi:10.1038/s41467-023-36406-2

Nature Communications (Feb 2023)

A single-cell transcriptional atlas reveals resident progenitor cell niche functions in TMJ disc development and injury

Ruiye Bi,
Qing Yin,
Haohan Li,
Xianni Yang,
Yiru Wang,
Qianli Li,
Han Fang,
Peiran Li,
Ping Lyu,
Yi Fan,
Binbin Ying,
Songsong Zhu

Affiliations

Ruiye Bi: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University
Qing Yin: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University
Haohan Li: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University
Xianni Yang: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University
Yiru Wang: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University
Qianli Li: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University
Han Fang: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University
Peiran Li: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University
Ping Lyu: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University
Yi Fan: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University
Binbin Ying: Department of Stomatology, Ningbo First Hospital
Songsong Zhu: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthognathic and TMJ Surgery, West China Hospital of Stomatology, Sichuan University

DOI: https://doi.org/10.1038/s41467-023-36406-2
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 18

Abstract

Read online

The transcriptional network in TMJ disc development and injury remains poorly characterized. Here they generate a scRNA-seq atlas of mouse TMJ disc, and identify the resident progenitor population and how its transcriptional reprogramming contributes to disc repair.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal