Frontiers in Oncology (Jul 2024)
Predicting immune checkpoint therapy response in three independent metastatic melanoma cohorts
- Leticia Szadai,
- Aron Bartha,
- Aron Bartha,
- Indira Pla Parada,
- Alexandra I.T. Lakatos,
- Alexandra I.T. Lakatos,
- Alexandra I.T. Lakatos,
- Dorottya M.P. Pál,
- Dorottya M.P. Pál,
- Dorottya M.P. Pál,
- Anna Sára Lengyel,
- Anna Sára Lengyel,
- Anna Sára Lengyel,
- Natália Pinto de Almeida,
- Natália Pinto de Almeida,
- Ágnes Judit Jánosi,
- Fábio Nogueira,
- Beata Szeitz,
- Viktória Doma,
- Nicole Woldmar,
- Nicole Woldmar,
- Jéssica Guedes,
- Jéssica Guedes,
- Zsuzsanna Ujfaludi,
- Zsuzsanna Ujfaludi,
- Zoltán Gábor Pahi,
- Zoltán Gábor Pahi,
- Zoltán Gábor Pahi,
- Tibor Pankotai,
- Tibor Pankotai,
- Tibor Pankotai,
- Yonghyo Kim,
- Balázs Győrffy,
- Balázs Győrffy,
- Bo Baldetorp,
- Charlotte Welinder,
- A. Marcell Szasz,
- Lazaro Betancourt,
- Jeovanis Gil,
- Roger Appelqvist,
- Ho Jeong Kwon,
- Sarolta Kárpáti,
- Magdalena Kuras,
- Jimmy Rodriguez Murillo,
- István Balázs Németh,
- Johan Malm,
- David Fenyö,
- Krzysztof Pawłowski,
- Peter Horvatovich,
- Elisabet Wieslander,
- Lajos V. Kemény,
- Lajos V. Kemény,
- Lajos V. Kemény,
- Gilberto Domont,
- György Marko-Varga,
- György Marko-Varga,
- Aniel Sanchez
Affiliations
- Leticia Szadai
- Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary
- Aron Bartha
- Department of Bioinformatics, Semmelweis University, Budapest, Hungary
- Aron Bartha
- Department of Pediatrics, Semmelweis University, Budapest, Hungary
- Indira Pla Parada
- Section for Clinical Chemistry, Department of Translational Medicine, Lund University, Skåne University Hospital Malmö, Malmö, Sweden
- Alexandra I.T. Lakatos
- HCEMM-SU Translational Dermatology Research Group, Semmelweis University, Budapest, Hungary
- Alexandra I.T. Lakatos
- Department of Physiology, Semmelweis University, Budapest, Hungary
- Alexandra I.T. Lakatos
- Department of Dermatology, Venereology, and Dermatooncology, Semmelweis University, Budapest, Hungary
- Dorottya M.P. Pál
- HCEMM-SU Translational Dermatology Research Group, Semmelweis University, Budapest, Hungary
- Dorottya M.P. Pál
- Department of Physiology, Semmelweis University, Budapest, Hungary
- Dorottya M.P. Pál
- Department of Dermatology, Venereology, and Dermatooncology, Semmelweis University, Budapest, Hungary
- Anna Sára Lengyel
- HCEMM-SU Translational Dermatology Research Group, Semmelweis University, Budapest, Hungary
- Anna Sára Lengyel
- Department of Physiology, Semmelweis University, Budapest, Hungary
- Anna Sára Lengyel
- Department of Dermatology, Venereology, and Dermatooncology, Semmelweis University, Budapest, Hungary
- Natália Pinto de Almeida
- Clinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lund University, Lund, Sweden
- Natália Pinto de Almeida
- Chemistry Institute Federal, University of Rio de Janeiro, Rio de Janiero, Brazil
- Ágnes Judit Jánosi
- Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary
- Fábio Nogueira
- Chemistry Institute Federal, University of Rio de Janeiro, Rio de Janiero, Brazil
- Beata Szeitz
- 0Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary
- Viktória Doma
- Department of Dermatology, Venereology, and Dermatooncology, Semmelweis University, Budapest, Hungary
- Nicole Woldmar
- Clinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lund University, Lund, Sweden
- Nicole Woldmar
- Chemistry Institute Federal, University of Rio de Janeiro, Rio de Janiero, Brazil
- Jéssica Guedes
- Section for Clinical Chemistry, Department of Translational Medicine, Lund University, Skåne University Hospital Malmö, Malmö, Sweden
- Jéssica Guedes
- Clinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lund University, Lund, Sweden
- Zsuzsanna Ujfaludi
- 1Department of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary
- Zsuzsanna Ujfaludi
- 2Competence Centre of the Life Sciences Cluster of the Centre of Excellence for Interdisciplinary Research, Development and Innovation, University of Szeged, Szeged, Hungary
- Zoltán Gábor Pahi
- 1Department of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary
- Zoltán Gábor Pahi
- 2Competence Centre of the Life Sciences Cluster of the Centre of Excellence for Interdisciplinary Research, Development and Innovation, University of Szeged, Szeged, Hungary
- Zoltán Gábor Pahi
- 3Hungarian Centre of Excellence for Molecular Medicine (HCEMM), Genome Integrity and DNA Repair Core Group, University of Szeged, Szeged, Hungary
- Tibor Pankotai
- 1Department of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary
- Tibor Pankotai
- 2Competence Centre of the Life Sciences Cluster of the Centre of Excellence for Interdisciplinary Research, Development and Innovation, University of Szeged, Szeged, Hungary
- Tibor Pankotai
- 3Hungarian Centre of Excellence for Molecular Medicine (HCEMM), Genome Integrity and DNA Repair Core Group, University of Szeged, Szeged, Hungary
- Yonghyo Kim
- 4Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology (KRICT), Daejeon, Republic of Korea
- Balázs Győrffy
- Department of Bioinformatics, Semmelweis University, Budapest, Hungary
- Balázs Győrffy
- 5Research Centre for Natural Sciences, Institute of Molecular Life Sciences, Budapest, Hungary
- Bo Baldetorp
- 6Division of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden
- Charlotte Welinder
- 6Division of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden
- A. Marcell Szasz
- 0Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary
- Lazaro Betancourt
- Clinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lund University, Lund, Sweden
- Jeovanis Gil
- Clinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lund University, Lund, Sweden
- Roger Appelqvist
- Clinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lund University, Lund, Sweden
- Ho Jeong Kwon
- 7Chemical Genomics Global Research Lab, Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea
- Sarolta Kárpáti
- Department of Dermatology, Venereology, and Dermatooncology, Semmelweis University, Budapest, Hungary
- Magdalena Kuras
- Clinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lund University, Lund, Sweden
- Jimmy Rodriguez Murillo
- 8Department of Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
- István Balázs Németh
- Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary
- Johan Malm
- Section for Clinical Chemistry, Department of Translational Medicine, Lund University, Skåne University Hospital Malmö, Malmö, Sweden
- David Fenyö
- 9Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, United States
- Krzysztof Pawłowski
- 0Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, United States
- Peter Horvatovich
- 1Analytical Biochemistry, Department of Pharmacy, University of Groningen, Groningen, Netherlands
- Elisabet Wieslander
- 6Division of Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden
- Lajos V. Kemény
- HCEMM-SU Translational Dermatology Research Group, Semmelweis University, Budapest, Hungary
- Lajos V. Kemény
- Department of Physiology, Semmelweis University, Budapest, Hungary
- Lajos V. Kemény
- Department of Dermatology, Venereology, and Dermatooncology, Semmelweis University, Budapest, Hungary
- Gilberto Domont
- Chemistry Institute Federal, University of Rio de Janeiro, Rio de Janiero, Brazil
- György Marko-Varga
- Clinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lund University, Lund, Sweden
- György Marko-Varga
- 2First Department of Surgery, Tokyo Medical University, Nishishinjiku, Shinjiku-ku, Tokyo, Japan
- Aniel Sanchez
- Section for Clinical Chemistry, Department of Translational Medicine, Lund University, Skåne University Hospital Malmö, Malmö, Sweden
- DOI
- https://doi.org/10.3389/fonc.2024.1428182
- Journal volume & issue
-
Vol. 14
Abstract
IntroductionWhile Immune checkpoint inhibition (ICI) therapy shows significant efficacy in metastatic melanoma, only about 50% respond, lacking reliable predictive methods. We introduce a panel of six proteins aimed at predicting response to ICI therapy.MethodsEvaluating previously reported proteins in two untreated melanoma cohorts, we used a published predictive model (EaSIeR score) to identify potential proteins distinguishing responders and non-responders.ResultsSix proteins initially identified in the ICI cohort correlated with predicted response in the untreated cohort. Additionally, three proteins correlated with patient survival, both at the protein, and at the transcript levels, in an independent immunotherapy treated cohort.DiscussionOur study identifies predictive biomarkers across three melanoma cohorts, suggesting their use in therapeutic decision-making.
Keywords
