Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection

Armin P. Schoech; Daniel M. Jordan; Po-Ru Loh; Steven Gazal; Luke J. O’Connor; Daniel J. Balick; Pier F. Palamara; Hilary K. Finucane; Shamil R. Sunyaev; Alkes L. Price

doi:10.1038/s41467-019-08424-6

Nature Communications (Feb 2019)

Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection

Armin P. Schoech,
Daniel M. Jordan,
Po-Ru Loh,
Steven Gazal,
Luke J. O’Connor,
Daniel J. Balick,
Pier F. Palamara,
Hilary K. Finucane,
Shamil R. Sunyaev,
Alkes L. Price

Affiliations

Armin P. Schoech: Department of Epidemiology, Harvard T.H. Chan School of Public Health
Daniel M. Jordan: Charles R. Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
Po-Ru Loh: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
Steven Gazal: Department of Epidemiology, Harvard T.H. Chan School of Public Health
Luke J. O’Connor: Department of Epidemiology, Harvard T.H. Chan School of Public Health
Daniel J. Balick: Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Pier F. Palamara: Department of Statistics, University of Oxford
Hilary K. Finucane: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
Shamil R. Sunyaev: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
Alkes L. Price: Department of Epidemiology, Harvard T.H. Chan School of Public Health

DOI: https://doi.org/10.1038/s41467-019-08424-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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Negative selection removes deleterious genetic variation, and can influence genetic architectures and evolution of complex traits. Here, the authors analyze data from 25 UK Biobank diseases and complex traits, and quantify frequency-dependent genetic architectures which suggests actions of negative selection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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