Качественная клиническая практика (May 2018)
Preliminary results of investigation regarding influence of sacubitril/valsartan supramolecular complex on healthcare resource consumption
Abstract
Chronic heart failure (CHF) is a disease characterized by a number of typical symptoms, which are related to inadequate blood perfusion of internal organs both at rest and under exercise, which often also leads to liquid retention. It has poor prognosis and constitutes considerable burden on healthcare system. Supramolecular sacubitril/valsartan complex has been shown to significantly reduce frequency of hospitalization and emergency room visits in international RCT's. This indicates that there is a significant interest in performing local, Russian studies focusing on effects of using sacubitril/valsartan may have on healthcare system burden. Methodology. Epidemiological characteristics of patients with CHF receiving “standard” care were assessed. 75 healthcare professionals have been questionnaired to investigate patient parameters and significant event frequency. The study was carried out in 10 large cities of Russian Federation. Effects of switching patients to the new therapy were also assessed. Results. It was confirmed that epidemiological properties of patient population is within parameters found during previous large Russian epidemiological studies. It was found that utilization of sacubitril/valsartan is associated with significant reduction in healthcare resource utilization due to reduction in hospitalizations and emergency service use. Per 3 month of observation, patients receiving standard treatment had average hospitalization frequency of 0,8 and a similar frequency of requiring ambulance dispatch. Switching patients to sacubitril/valsartan resulted in drop of hospitalization frequency to 0,3 (per 3 month of observation) and a similar reduction of ambulance calls. Conclusions. Preliminary analysis of data obtained during this study confirms high efficacy of new therapy using sacubitril/valsartan supramolecular complex within Russian healthcare, specifically regarding reduction of clinically significant unfavorable events such as hospitalizations and ambulance calls. This indicates that this treatment approach has potentially beneficial effect on burden experienced by medical facilities and expedience of carrying out further research in this direction.
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