Preoperative intensity-modulated chemoradiotherapy with simultaneous integrated boost in rectal cancer: five-year follow-up results of a phase II study

Abstract

We conducted a phase II study to investigate the feasibility and safety of preoperative radiochemo-therapy experimental fractionation, using intensity-modulated radiation therapy with simultaneous integrated boost (IMRT SIB) to shorten the overall treatment time without dose escalation in intermediate/locally advanced rectal cancer with the aim to improving treatment outcome.

Keywords

• rectal cancer
• imrt
• simultaneous integrated boost
• preoperative radiochemotherapy
• acute toxicity
• pathologic complete response
• overall survival
• disease-free survival
• local control
• late toxicity
• quality of life