Zhongguo quanke yixue (Dec 2022)
Correlation between Serum Thyroid Hormone and Hyperuricemia in Euthyroid Hypertensive Patients
Abstract
Background Hypertension is closely related to serum uric acid (SUA) level, and often accompanied by thyroid function changes. However, there are few reports on the relationship between thyroid hormone level and hyperuricemia (HUA) in euthyroid hypertensive patients. Objective To explore the correlation between serum thyroid hormone level and HUA in euthyroid individuals with essential hypertension (EH) . Methods Two hundred and sixty-seven euthyroid patients with EH were retrospectively selected from Department of Cardiology, Xianyang Hospital of Yan'an University from January 2019 to December 2020, including 101 with HUA (combined HUA group) and 166 without HUA (non-HUA group) . The general demographic data and laboratory examination indices of the two groups were compared, including gender, age, body mass index (BMI) , systolic blood pressure (SBP) , diastolic blood pressure (DBP) , smoking history, drinking history, total cholesterol (TC) , triacylglycerol (TG) , high-density lipoprotein cholesterol (HDL-C) , low-density lipoprotein cholesterol (LDL-C) , serum creatinine (Scr) , SUA, thyroid-stimulating hormone (TSH) , free triiodothyronine (FT3) , and free thyroxine (FT4) . Multivariate Logistic regression analysis was used to explore factors associated with HUA. Pearson correlation was used to examine the correlation between thyroid hormone level and SUA level. Results There were significant intergroup differences in gender ratio, mean age, BMI, and DBP, as well as prevalence of smoking history and drinking history (P<0.05) . Moreover, the mean levels of TC, TG, LDL-C, Scr and SUA were also significantly different in the two groups (P<0.05) . In particular, the mean level of FT3 in combined HUA group was significantly higher (t=-5.066, P<0.05) . Multivariate Logistic regression analysis demonstrated that male〔OR=2.843, 95%CI (1.121, 7.215) , P=0.028〕, higher BMI〔OR=1.126, 95%CI (1.020, 1.234) , P=0.018〕, TG〔OR=1.824, 95%CI (1.300, 2.560) , P=0.001〕, LDL-C〔OR=2.804, 95%CI (1.157, 6.795) , P=0.022〕, Scr〔OR=1.071, 95%CI (1.041, 1.102) , P<0.001〕and FT3〔OR=2.297, 95%CI (1.326, 3.977) , P=0.003〕were associated with increased risk of HUA. Advanced age〔OR=0.959, 95%CI (0.931, 0.989) , P=0.007〕was decreased risk of HUA. Pearson correlation analysis revealed that the level of FT3 was positively correlated with SUA (r=0.327, P<0.001) . Conclusion Being male, high BMI, elevated TG, LDL-C, Scr and FT3 levels may be risk factors for HUA in euthyroid patients with EH. Advanced age may be protective factor for HUA in euthyroid patients with EH. As FT3 level is positively correlated with SUA in these patients, those with elevated serum FT3 level are prone to HUA, which should be paid attention by clinicians.
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