Frontiers in Microbiology (Mar 2021)

New Thio-Compounds and Monoterpenes With Anti-inflammatory Activities From the Fungus Aspergillus sp. CYH26

  • Guojun Pan,
  • Yanling Li,
  • Xinyu Che,
  • Dan Tian,
  • Wenjie Han,
  • Zimin Wang,
  • Yanfen Zhao,
  • Shuang Ren,
  • Yiru Xu,
  • Gangping Hao,
  • Mengfei Guo,
  • Na Xiao,
  • Na Xiao,
  • Fandong Kong

DOI
https://doi.org/10.3389/fmicb.2021.668938
Journal volume & issue
Vol. 12

Abstract

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Two new thio-compounds named aspergerthinol A and B (1 and 2) and two new monoterpenes named aspergerthinacids A and B (3 and 4) were isolated from the fungus Aspergillus sp. CYH26 from the rhizosphere soil of Cynanchum bungei Decne. The structures of compounds were elucidated by spectroscopic data and quantum NMR and ECD calculations. Compounds 1 and 2 represented a new family of sulfur containing natural products with a 3-methyl-4H-cyclopenta[b]thiophen-4-one skeleton. Compounds 1–4 showed inhibitory activities against nitric oxide (NO) with IC50 values of 38.0, 19.8, 46.3, and 56.6 μM, respectively.

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