Frontiers in Neurology (May 2024)

Efficacy and safety of transcranial pulse stimulation in young adolescents with attention-deficit/hyperactivity disorder: a pilot, randomized, double-blind, sham-controlled trial

  • Teris Cheung,
  • Teris Cheung,
  • Benjamin K. Yee,
  • Benjamin K. Yee,
  • Bolton Chau,
  • Bolton Chau,
  • Joyce Yuen Ting Lam,
  • Joyce Yuen Ting Lam,
  • Kwan Hin Fong,
  • Herman Lo,
  • Tim Man Ho Li,
  • Albert Martin Li,
  • Lei Sun,
  • Roland Beisteiner,
  • Calvin Pak Wing Cheng

DOI
https://doi.org/10.3389/fneur.2024.1364270
Journal volume & issue
Vol. 15

Abstract

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BackgroundThis is the first study to evaluate the efficacy and safety of transcranial pulse stimulation (TPS) for the treatment of attention-deficit/hyperactivity disorder (ADHD) among young adolescents in Hong Kong.MethodsThis double-blind, randomized, sham-controlled trial included a TPS group and a sham TPS group, encompassing a total of 30 subjects aged 12–17 years who were diagnosed with ADHD. Baseline measurements SNAP-IV, ADHD RS-IV, CGI and executive functions (Stroop tests, Digit Span) and post-TPS evaluation were collected. Both groups were assessed at baseline, immediately after intervention, and at 1-month and 3-month follow-ups. Repeated-measures ANOVAs were used to analyze data.ResultsThe TPS group exhibited a 30% reduction in the mean SNAP-IV score at postintervention that was maintained at 1- and 3-month follow-ups.ConclusionTPS is an effective and safe adjunct treatment for the clinical management of ADHD.Clinical trial registrationClinicalTrials.Gov, identifier NCT05422274.

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