Lipid profiles and inflammatory markers after periodontal treatment in children with congenital heart disease and at risk for atherosclerosis

Abstract

Adriana Chassot Bresolin,1 Mariana Menegassi Pronsatti,2 Larissa Nicole Pasqualotto,2 Patricia Oehlmeyer Nassar,3 Alex Sandro Jorge,4 Edson Antonio Alves da Silva,5 Carlos Augusto Nassar3 1Department of Biosciences and Health, 2School of Dentistry, 3Department of Periodontology, 4School of Biochemistry, 5Graduate Program, Western Paraná State University (UNIOESTE), Cascavel, Paraná, Brazil Abstract: Due to the biological associations between periodontal and cardiovascular diseases, as well as the fact that atherosclerosis begins in childhood, behavior based on oral health care and metabolic control from an early age is essential for patients with cardiovascular disease. The aim of this research was to examine the effect of full-mouth scaling and root planing on the reduction of periodontal disease in children with congenital heart disease. In this study, treatments were related to clinical periodontal parameters and also to blood ones, such as lipid profile and inflammatory markers. The patients were divided into two groups: group 1 (n=17), scaling and root planing; and group 2 (n=16), full-mouth scaling and root planing. The results showed a significant improvement in clinical periodontal parameters (P<0.05) in both groups. Considering lipid parameters, total cholesterol, triglycerides, and very-low-density lipoprotein parameters showed significant improvement (P<0.05). There was also an improvement in C-reactive protein (ultrasensitive) in the group treated with scaling and root planing (P<0.05). Fibrinogen and interleukin-6 parameters improved (P<0.05) in both groups. We suggest that both periodontal treatments were effective in children with congenital heart disease, though neither demonstrated superiority. Keywords: periodontal disease, heart defects, congenital, lipid metabolism, inflammation mediators, children