A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs

Raquel M. Melero-Fernandez de Mera; Li-Li Li; Arkadiusz Popinigis; Katryna Cisek; Minna Tuittila; Leena Yadav; Andrius Serva; Michael J. Courtney

doi:10.1038/ncomms15017

Nature Communications (May 2017)

A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs

Raquel M. Melero-Fernandez de Mera,
Li-Li Li,
Arkadiusz Popinigis,
Katryna Cisek,
Minna Tuittila,
Leena Yadav,
Andrius Serva,
Michael J. Courtney

Affiliations

Raquel M. Melero-Fernandez de Mera: Molecular Signalling Laboratory, A.I. Virtanen Institute, University of Eastern Finland
Li-Li Li: Molecular Signalling Laboratory, A.I. Virtanen Institute, University of Eastern Finland
Arkadiusz Popinigis: Neuronal Signalling Laboratory, Turku Centre for Biotechnology, University of Turku and Åbo Akademi University
Katryna Cisek: Molecular Signalling Laboratory, A.I. Virtanen Institute, University of Eastern Finland
Minna Tuittila: Neuronal Signalling Laboratory, Turku Centre for Biotechnology, University of Turku and Åbo Akademi University
Leena Yadav: Molecular Signalling Laboratory, A.I. Virtanen Institute, University of Eastern Finland
Andrius Serva: Molecular Signalling Laboratory, A.I. Virtanen Institute, University of Eastern Finland
Michael J. Courtney: Molecular Signalling Laboratory, A.I. Virtanen Institute, University of Eastern Finland

DOI: https://doi.org/10.1038/ncomms15017
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 18

Abstract

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Light-sensitive regulators of protein kinases could offer valuable insights into intracellular signalling. Here the authors design an optogenetic inhibitor of c-Jun N-terminal kinase (JNK) and show evidence for resonance in JNK signalling circuits in neurons, and use the same design principle to develop an inhibitor for p38MAPK.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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