Nature Communications (Jun 2020)
Using arterial–venous analysis to characterize cancer metabolic consumption in patients
- Nanxiang Xiong,
- Xiaofei Gao,
- Hongyang Zhao,
- Feng Cai,
- Fang-cheng Zhang,
- Ye Yuan,
- Weichao Liu,
- Fangping He,
- Lauren G. Zacharias,
- Hong Lin,
- Hieu S. Vu,
- Chao Xing,
- Dong-Xiao Yao,
- Fei Chen,
- Benyan Luo,
- Wenzhi Sun,
- Ralph J. DeBerardinis,
- Hao Xu,
- Woo-ping Ge
Affiliations
- Nanxiang Xiong
- Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Xiaofei Gao
- Children’s Research Institute, University of Texas Southwestern Medical Center
- Hongyang Zhao
- Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Feng Cai
- Children’s Research Institute, University of Texas Southwestern Medical Center
- Fang-cheng Zhang
- Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Ye Yuan
- Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Weichao Liu
- Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Fangping He
- Department of Neurology, First Affiliated Hospital, School of Medicine, Zhejiang University
- Lauren G. Zacharias
- Children’s Research Institute, University of Texas Southwestern Medical Center
- Hong Lin
- Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Hieu S. Vu
- Children’s Research Institute, University of Texas Southwestern Medical Center
- Chao Xing
- Eugene McDermott Center for Human Growth and Development, Department of Bioinformatics, Department of Population and Data Sciences, University of Texas Southwestern Medical Center
- Dong-Xiao Yao
- Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Fei Chen
- Children’s Research Institute, University of Texas Southwestern Medical Center
- Benyan Luo
- Eugene McDermott Center for Human Growth and Development, Department of Bioinformatics, Department of Population and Data Sciences, University of Texas Southwestern Medical Center
- Wenzhi Sun
- Chinese Institute for Brain Research, Beijing
- Ralph J. DeBerardinis
- Children’s Research Institute, University of Texas Southwestern Medical Center
- Hao Xu
- Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Woo-ping Ge
- Chinese Institute for Brain Research, Beijing
- DOI
- https://doi.org/10.1038/s41467-020-16810-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 9
Abstract
Cellular metabolism is altered in many cancer types and the advent of metabolomics has allowed us to understand more about how this is dysregulated. Here, the authors report a method named CARVE to analyse the arterial supply and venous drainage of glioma patients during surgery and identify the metabolites that may be consumed and produced by the cancer.
