Study of trace elements in type 2 diabetes mellitus with special Reference to iron and magnesium indicating significance for early detection of complications

Abstract

Background: Diabetes mellitus is a group of etiologically different metabolic defects characterized by hyperglycemia resulting from defect in insulin secretion as well as insulin action or both. The role of trace elements in type 2 diabetes like serum magnesium and total serum iron is essential in glucose homeostasis at multiple levels with complex interplay which exist between glucose and magnesium. The aim of the study was to determine the role of iron and magnesium in type 2 diabetes and its complications. Objective: To identify the persons with type 2 diabetes mellitus and state their iron status, magnesium levels in serum for early detection of risk factors which indicate the severity of diabetes and its complications. Methods: A total of 50 subjects aged >35 years were selected from Chalmeda Anand Rao institute of medical sciences, Bommakal, Karimnagar. Total serum iron is determined by Ferrozine method, serum magnesium is determined by xylidyl blue with ATCS method. Results: The mean and SD of serum Random Blood Glucose in controls is 114.5±9.75 as compared to 207.5±31.5 in cases. The mean and S.D of serum Iron in control is 114.36±20.35 as compared to 286.08± 96.35 in cases. The mean and S.D of serum Magnesium in control is 1.9±0.1 as compared to 0.88± 0.1 in cases. Conclusion: Our study was concluded that serum magnesium is decreased and serum total iron is increased in type 2 diabetes which plays a pathogenic role in diabetes and its complications

Keywords

• type 2 diabetes
• iron
• magnesium
• insulin resistance