In vivo inhibition of gastric acid secretions and H+/K+- ATPase activity, and enhancement of mucin activity by Dissotis rotundifolia plant extract

Abstract

Gastric H+/K+ ATPase enzyme is a central biomolecule that controls gastric secretions and its inhibition is reported to correlate with healing and symptomatic relief in both gastroesophageal reflux disease and peptic ulcers patients. The current study was done to assess the claim that Dissotis rotundifolia possesses anti-ulcer potentials. The experiment was done on Aspirin (acetylsalicylic acid)-induced gastric ulcer rats to ascertain the ability of the plant extract in protecting against gastric ulcer. Histological investigation of gastric lesions and physical examinations of the stomach lining were carried out together with evaluation of gastric secretions. There was experimental evidence in rats to support the purported effectiveness of the plant in the management of gastrointestinal ulceration. The data shows that Dissotis rotundifolia extract at 300 mg/kgbwt acts as an antiulcer agent by serving as a proton pump inhibitor that also increases mucin activity, gastric mucus content, pH but decreases titrable acidity. This was confirmed in the observation of a marked reduction in gastric mucosal damage affirmed by histology in DR-pre-treated groups compared to negative control groups.

Keywords

• Dissotis rotundifolia
• Acetylsalicylic acid
• H+/k+atpase