The Relationship between AB0/Rhesus Blood Group Antigens with the Presence of Helicobacter pylori in Gastroduodenal Biopsy- Retrospective Analyze of 1774 Patient Data

Abstract

INTRODUCTION: Research on risk factors for the worldwide common carcinogen H. pylori infection has continued. In this study, we aimed to identify the presence of a risky blood group for H. pylori infection and premalignant lesions (atrophy and intestinal metaplasia) of the stomach. METHODS: The data of aged 18 and older 1774 patients with the presence of H. pylori in pathological examinations after performing gastroduodenal endoscopy in the gastroenterology clinic between the dates of 01.01.2021 and 10.01.2022 were used to analyze the retrospective case-control study. A virtual group distributed according to the blood group and gender ratios of the general population was formed as the control group. Multivariate logistic regression was performed to investigate the effect of blood type, Rh status, and gender on H. pylori infection. Values with a p-value of <0.05 were considered significant. RESULTS: 61% of the patients were female and the mean age was 51 years. The blood group ratios of all patients and patients with precancerous lesions were found to be close to the general of the country. The difference in Rh positivity was not significant (p=0.33). The higher rate of female gender in the patient group was found to be significant (p<0.001). Blood group distribution of patients with premalignant lesions was close to the general of the country. Intestinal metaplasia was more frequent than atrophy (17% vs. 5.7%). DISCUSSION AND CONCLUSION: No relationship was found between H. pylori infection and premalignant lesions with blood groups, but its higher incidence in females may shed light on new research based on gender.

Keywords

• blood groups
• biopsy
• endoscopy
• gastrointestinal
• helicobacter pylori