Nature Communications (Jan 2020)
Golgi organization is regulated by proteasomal degradation
- Avital Eisenberg-Lerner,
- Ron Benyair,
- Noa Hizkiahou,
- Neta Nudel,
- Roey Maor,
- Matthias P. Kramer,
- Merav D. Shmueli,
- Inbal Zigdon,
- Marina Cherniavsky Lev,
- Adi Ulman,
- Jitka Yehudith Sagiv,
- Molly Dayan,
- Bareket Dassa,
- Mercedes Rosenwald,
- Idit Shachar,
- Jie Li,
- Yanzhuang Wang,
- Nili Dezorella,
- Suman Khan,
- Ziv Porat,
- Eyal Shimoni,
- Ori Avinoam,
- Yifat Merbl
Affiliations
- Avital Eisenberg-Lerner
- Department of Immunology, Weizmann Institute of Science
- Ron Benyair
- Department of Immunology, Weizmann Institute of Science
- Noa Hizkiahou
- Department of Immunology, Weizmann Institute of Science
- Neta Nudel
- Department of Immunology, Weizmann Institute of Science
- Roey Maor
- Department of Immunology, Weizmann Institute of Science
- Matthias P. Kramer
- Department of Immunology, Weizmann Institute of Science
- Merav D. Shmueli
- Department of Immunology, Weizmann Institute of Science
- Inbal Zigdon
- Department of Immunology, Weizmann Institute of Science
- Marina Cherniavsky Lev
- Department of Immunology, Weizmann Institute of Science
- Adi Ulman
- Department of Immunology, Weizmann Institute of Science
- Jitka Yehudith Sagiv
- Department of Immunology, Weizmann Institute of Science
- Molly Dayan
- Department of Immunology, Weizmann Institute of Science
- Bareket Dassa
- Department of Immunology, Weizmann Institute of Science
- Mercedes Rosenwald
- Department of Immunology, Weizmann Institute of Science
- Idit Shachar
- Department of Immunology, Weizmann Institute of Science
- Jie Li
- Department of Molecular, Cellular and Developmental Biology, University of Michigan
- Yanzhuang Wang
- Department of Molecular, Cellular and Developmental Biology, University of Michigan
- Nili Dezorella
- Department of Chemical Research Support, Weizmann Institute of Science
- Suman Khan
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Ziv Porat
- Flow Cytometry Unit, Life Sciences Core Facilities, Weizmann Institute of Science
- Eyal Shimoni
- Department of Chemical Research Support, Weizmann Institute of Science
- Ori Avinoam
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Yifat Merbl
- Department of Immunology, Weizmann Institute of Science
- DOI
- https://doi.org/10.1038/s41467-019-14038-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Correct Golgi assembly is important to cellular homeostasis but regulation of its structure under stress remains unclear. Here, the authors identify stress-induced degradation of GM130 by Golgi-localized 26S proteasomes, leading to Golgi dispersal.
