Hybrid graphene electrode for the diagnosis and treatment of epilepsy in free-moving animal models

Abstract

Abstract Various electrophysiological and imaging techniques have been studied for the diagnosis and treatment of epilepsy. In particular, electrocorticography (ECoG) provides valuable information that can guide clinical treatment of patients with epilepsy. Currently, it is necessary to define the clinical benefits of ECoG in free-moving animals for the treatment of epilepsy. Here, we present the results of simultaneous recordings of multiple cortical sites and responsive neurostimulations for epilepsy treatment carried out in free-moving rats. In this study, we developed a high-density, flexible electrode array comprising graphene/Au/graphene that stably wraps onto the cortex surface of a living rat brain, exhibiting a superior signal-to-noise ratio. The hybrid graphene multichannel electrode successfully detected brain signals with high-throughput spatiotemporal resolution and substantially suppressed pilocarpine-induced epileptic discharges and behavior. Simultaneous recording and neurostimulation in awake animals can lead to a fundamental change in the treatment of medically intractable epilepsy.