The Bioscientist (May 2023)
THE EFFECTIVENESS OF PHYTOPHARMACA OF EXTRACTS GARCINIA KOLA(HECKEL) ROOT ON CHANGES INBODY WEIGHT, SERUM BIOCHEMICAL PARAMETERS AND HISTOLOGICAL PROFILES OF WISTAR RATS
Abstract
The effect of solvents extracts of G. kola administered to rats at 50, 250 and 500 mg/kg for two weeks was investigated on body weight and serum biochemical parameters using standard analytical-biochemical methods. The extracts at all doses investigated proved that only the 250 mg/kg of the aqueous and methanolroot extracts were able to reduce rat’s body weights. Rats given the methanol extract had no significant differences in the values of AST, total protein, cholesterol, total bilirubin, and urea whereas had significantly increased ALP activity, and albumin content (at all doses used) and direct bilirubin (at 250 mg/ kg), compared to control (p<0.05). Rats dosed with the aqueousextract showed higher AST activity but comparable ALT and ALP activities to that of control. Compared to control values total protein and D.Bwere significantly lower in the three treated groups, T.B and albumin were significantly lower at the 250 and 500 dose levels (p<0.05). Cholesterol was significantly low in the 250 dose group and no significant difference was observed for urea levels. In the vital organ, there were no lesions or evidence of hepatotoxicity. The little alterations in some parameters indicated that the root extracts of G. kola possess slight toxicity. Therefore, crude extracts of rootshould be taken with caution for safety.
