AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A

Alexandra K. Davies; Daniel N. Itzhak; James R. Edgar; Tara L. Archuleta; Jennifer Hirst; Lauren P. Jackson; Margaret S. Robinson; Georg H. H. Borner

doi:10.1038/s41467-018-06172-7

Nature Communications (Sep 2018)

AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A

Alexandra K. Davies,
Daniel N. Itzhak,
James R. Edgar,
Tara L. Archuleta,
Jennifer Hirst,
Lauren P. Jackson,
Margaret S. Robinson,
Georg H. H. Borner

Affiliations

Alexandra K. Davies: Cambridge Institute for Medical Research, University of Cambridge
Daniel N. Itzhak: Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry
James R. Edgar: Cambridge Institute for Medical Research, University of Cambridge
Tara L. Archuleta: Department of Biological Sciences, Vanderbilt University
Jennifer Hirst: Cambridge Institute for Medical Research, University of Cambridge
Lauren P. Jackson: Department of Biological Sciences, Vanderbilt University
Margaret S. Robinson: Cambridge Institute for Medical Research, University of Cambridge
Georg H. H. Borner: Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry

DOI: https://doi.org/10.1038/s41467-018-06172-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 21

Abstract

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Adaptor protein complex 4 (AP-4) deficiency causes a severe neurological disorder via an unknown mechanism. Here, the authors reveal cargo and machinery of the AP-4 transport pathway, and propose that AP-4 mediates spatial regulation of autophagy through peripheral delivery of ATG9A.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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