Diabetes, Metabolic Syndrome and Obesity (May 2020)
Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study
Abstract
Zefeng Chen,1– 5 Yulan Bai,1– 5 Xinyang Long,1– 5 Qianqian Luo,1– 5 Zheng Wen,1– 5 Yuanfan Li,1– 5 Shengzhu Huang,1– 5 Yunkun Yan,1– 5 Zengnan Mo1– 4,6 1Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, Guangxi, People’s Republic of China; 2Guangxi Key Laboratory for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People’s Republic of China; 3Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Nanning 530021, Guangxi, People’s Republic of China; 4Guangxi Key Laboratory of Colleges and Universities, Nanning 530021, Guangxi, People’s Republic of China; 5School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, People’s Republic of China; 6Institute of Urology and Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, People’s Republic of ChinaCorrespondence: Zengnan MoCenter for Genomic and Personalized Medicine, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, People’s Republic of ChinaTel +86771-5353342Email [email protected]: The associations of adiponectin with type 2 diabetes mellitus (T2DM), glucose homeostasis (including β-cell function index (HOMA-β), insulin resistance (HOMA-IR), fasting insulin (FI) and fasting glucose (FG)) have reported in epidemiological studies. However, the previous observational studies are prone to biases, such as reverse causation and residual confounding factors. Herein, a Mendelian Randomization (MR) study was conducted to determine whether causal effects exist among them.Materials and and Methods: Two-sample MR analyses and multiple sensitivity analyses were performed using the summary data from the ADIPOGen consortium, MAGIC Consortium, and a meta-analysis of GWAS with a considerable sample of T2DM (62,892 cases and 596,424 controls of European ancestry). We got eight valid genetic variants to predict the causal effect among adiponectin and T2DM and glucose homeostasis after excluding the probable invalid or pleiotropic variants.Results: Adiponectin was not associated with T2DM (odds ratio (OR) = 1.004; 95% confidence interval (CI): 0.740, 1.363) when using MR Egger after removing the invalid SNPs, and the results were consistent when using the other four methods. Similar results existed among adiponectin and HOMA-β, HOMA-IR, FI, FG.Conclusion: Our MR study revealed that adiponectin had no causal effect on T2DM and glucose homeostasis and that the associations among them in observational studies may be due to confounding factors.Keywords: GWASs, adiponectin, Mendelian randomization, T2DM, glucose homeostasis
