International Journal of Infectious Diseases (Jan 2022)
Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil
- Stephanie L.S. Penetra,
- Michele F.B. da Silva,
- Paola Resende,
- Anielle Pina-Costa,
- Heloisa F.P. Santos,
- Lusiele Guaraldo,
- Guilherme A. Calvet,
- Maria Ogrzewalska,
- Ighor Arantes,
- Ketiuce Zukeram,
- Mia F. de Araújo,
- Ana Beatriz Machado Lima,
- Renata Serrano Lopes,
- Larissa R. Lira-Silva,
- Isabella V. Moraes,
- Mayumi D. Wakimoto,
- Trevon L. Fuller,
- Claudia Raja Gabaglia,
- Otávio M. Espíndola,
- Myrna C. Bonaldo,
- Cláudio Tadeu Daniel-Ribeiro,
- Jimmy Whitworth,
- Chris Smith,
- Karin Nielsen-Saines,
- Alex Pauvolid-Correa,
- Marilda M. Siqueira,
- Patricia Brasil
Affiliations
- Stephanie L.S. Penetra
- Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil
- Michele F.B. da Silva
- Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil
- Paola Resende
- Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil
- Anielle Pina-Costa
- Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil; Serra dos Órgãos Education Foundation, Avenida Alberto Tôrres, 111 - Alto, Teresópolis, RJ, 25964-004, Brazil
- Heloisa F.P. Santos
- Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil
- Lusiele Guaraldo
- Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil
- Guilherme A. Calvet
- Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil
- Maria Ogrzewalska
- Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil
- Ighor Arantes
- Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil
- Ketiuce Zukeram
- Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil
- Mia F. de Araújo
- Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil
- Ana Beatriz Machado Lima
- Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil
- Renata Serrano Lopes
- Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil
- Larissa R. Lira-Silva
- Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil
- Isabella V. Moraes
- Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil
- Mayumi D. Wakimoto
- Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil
- Trevon L. Fuller
- Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil; University of California, Los Angeles (UCLA), Box 951752, 10833 Le Conte Avenue 22-442 MDCC, Los Angeles, CA, 90095-1752, USA
- Claudia Raja Gabaglia
- Biomedical Research Institute of Southern California (BRISC), 4263 Oceanside Blvd#106-159, Oceanside, CA, 92056, USA
- Otávio M. Espíndola
- Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil
- Myrna C. Bonaldo
- Laboratory of Molecular Biology, Oswaldo Cruz Institute, Fiocruz, Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ 21040-3608, Brazil
- Cláudio Tadeu Daniel-Ribeiro
- Department of Immunology, Oswaldo Cruz Institute, Fiocruz, Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil
- Jimmy Whitworth
- Department of Clinical Research, London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, United Kingdom
- Chris Smith
- Department of Clinical Research, London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, United Kingdom
- Karin Nielsen-Saines
- University of California, Los Angeles (UCLA), Box 951752, 10833 Le Conte Avenue 22-442 MDCC, Los Angeles, CA, 90095-1752, USA
- Alex Pauvolid-Correa
- Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil; Texas A&M University, 400 Bizzell St, College Station, TX, 778434, USA
- Marilda M. Siqueira
- Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil
- Patricia Brasil
- Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil; Corresponding author.
- Journal volume & issue
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Vol. 114
pp. 58 – 61
Abstract
We describe a case of prolonged COVID-19 caused by the SARS-CoV-2 Gamma variant in a fully vaccinated healthcare worker, 387 days after an infection caused by lineage B.1.1.33. Infections were confirmed by whole-genome sequencing and corroborated by the detection of neutralizing antibodies in convalescent serum samples. Considering the permanent exposure of this healthcare worker to SARS-CoV-2, the waning immunity after the first infection, the low efficacy of the inactivated vaccine at preventing COVID-19, the immune escape of the Gamma variant (VOC), and the burden of post-COVID syndrome, this individual would have benefited from an additional dose of a heterologous vaccine.