SFRP1 Negatively Modulates Pyroptosis of Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis: A Review

Ping Jiang; Ping Jiang; Kai Wei; Kai Wei; Cen Chang; Cen Chang; Jianan Zhao; Jianan Zhao; Runrun Zhang; Lingxia Xu; Lingxia Xu; Yehua Jin; Linshuai Xu; Linshuai Xu; Yiming Shi; Yiming Shi; Shicheng Guo; Shicheng Guo; Steven J. Schrodi; Steven J. Schrodi; Dongyi He; Dongyi He; Dongyi He

doi:10.3389/fimmu.2022.903475

Frontiers in Immunology (Jun 2022)

SFRP1 Negatively Modulates Pyroptosis of Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis: A Review

Ping Jiang,
Ping Jiang,
Kai Wei,
Kai Wei,
Cen Chang,
Cen Chang,
Jianan Zhao,
Jianan Zhao,
Runrun Zhang,
Lingxia Xu,
Lingxia Xu,
Yehua Jin,
Linshuai Xu,
Linshuai Xu,
Yiming Shi,
Yiming Shi,
Shicheng Guo,
Shicheng Guo,
Steven J. Schrodi,
Steven J. Schrodi,
Dongyi He,
Dongyi He,
Dongyi He

Affiliations

Ping Jiang: Guanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Ping Jiang: Department of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Kai Wei: Guanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Kai Wei: Department of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Cen Chang: Guanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Cen Chang: Department of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Jianan Zhao: Guanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Jianan Zhao: Department of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Runrun Zhang: Department of Rheumatology, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China
Lingxia Xu: Guanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Lingxia Xu: Department of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Yehua Jin: Department of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Linshuai Xu: Guanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Linshuai Xu: Department of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Yiming Shi: Guanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Yiming Shi: Department of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Shicheng Guo: Department of Medical Genetics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States
Shicheng Guo: Computation and Informatics in Biology and Medicine, University of Wisconsin-Madison, Madison, WI, United States
Steven J. Schrodi: Department of Medical Genetics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States
Steven J. Schrodi: Computation and Informatics in Biology and Medicine, University of Wisconsin-Madison, Madison, WI, United States
Dongyi He: Guanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Dongyi He: Department of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Dongyi He: Institute of Arthritis Research in Integrative Medicine, Academy of Traditional Chinese Medicine, Shanghai, China

DOI: https://doi.org/10.3389/fimmu.2022.903475
Journal volume & issue: Vol. 13

Abstract

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Secreted frizzled-related protein 1 (SFRP1) is a member of secretory glycoprotein SFRP family. As a primitive gene regulating cell growth, development and transformation, SFRP1 is widely expressed in human cells, including various cancer cells and fibroblast-like synoviocytes (FLS) of rheumatoid arthritis (RA). Deletion or silencing of SFRP1 involves epigenetic and other mechanisms, and participates in biological behaviors such as cell proliferation, migration and cell pyroptosis, which leads to disease progression and poor prognosis. In this review, we discuss the role of SFRP1 in the pathogenesis of RA-FLS and summarize different experimental platforms and recent research results. These are helpful for understanding the biological characteristics of SFRP1 in RA, especially the mechanism by which SFRP1 regulates RA-FLS pyroptosis through Wnt/β-catenin and Notch signaling pathways. In addition, the epigenetic regulation of SFRP1 in RA-FLS is emphasized, which may be considered as a promising biomarker and therapeutic target of RA.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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