ADVERSE EFFECTS OF LAPROL-604 ON PREGNANT WISTAR RATS

Abstract

The article reports the results of research Laprol-604-induced effects on general weight, liver weight of pregnant rats, and their food and water consumption. Pregnant Wistar rats were administered 0,125; 1,25 and 12,5 mg/kg Laprol-604 once daily by gavage from the second gestation day (GD) to the twentieth GD. Maternal toxicity of Laprol-604 indicated by deficits in weight gain, reduction of food consumption, increase in drinking regimen and largamente of liver weight were observed in 1-rst, 2-nd and 3-rd groups, during pregnancy. The severity Laprol-604 induced effects were dose-dependent. The lag in weight gain was particularly pronounced in the pregnant rats of the 2nd and 3-rd groups. Pregnant rats in the 2nd (1,25mg/kg) and 3-rd (12,5 mg/kg) groups failed to gain any weight until the last week of pregnancy. These weight gain deficits corresponded to significant reductions in food consumption throughout gestation. Liver weights of the Laprol-604 -exposed pregnant rats, except 1-rd group, were different from controls appreciably. It should be noted, while body weight was deficit, the relative liver weight of all Laprol-604 dosage groups was significantly increased.

Keywords

• laprol-604, polyols, surfactant, reproductive toxicity, pregnant rat, gestation day, liver weight, food consumption, water intake