Frontiers in Neurology (Aug 2024)

Management of Meige syndrome with bilateral trigeminal and facial nerves combing

  • Tingting Ying,
  • Tingting Ying,
  • Haopeng Wang,
  • Haopeng Wang,
  • Yinda Tang,
  • Yinda Tang,
  • Hua Zhao,
  • Hua Zhao,
  • Xiaomin Cai,
  • Xiaomin Cai,
  • Yiman Shen,
  • Yiman Shen,
  • Baimiao Wang,
  • Baimiao Wang,
  • Wanchun Zhu,
  • Wanchun Zhu,
  • Ping Zhou,
  • Ping Zhou,
  • Xin Zhang,
  • Xin Zhang,
  • Jun Zhong,
  • Jun Zhong,
  • Xinjun Wang,
  • Xinjun Wang,
  • Xudong Fu,
  • Xudong Fu,
  • Jin Zhu,
  • Jin Zhu,
  • Weituo Zhang,
  • Shiting Li,
  • Shiting Li

DOI
https://doi.org/10.3389/fneur.2024.1410531
Journal volume & issue
Vol. 15

Abstract

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ObjectiveMeige syndrome (MS) is an adult-onset segmental dystonia for which no satisfactory remedy currently exists. Our team developed a novel surgical approach called bilateral trigeminal/facial nerve combing (BTFC). This study aimed to evaluate the outcomes of patients who underwent BFTC (Clinical Trial Registry Number: ChiCTR2000033481).MethodWe assigned 22 patients with MS to undergo BTFC. The primary outcome was assessed using the movement subscale of the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS-M) at 12 months postoperatively. The second outcome was evaluated using the Medical Outcome Study (MOS) 36-item Short Form Health Survey (SF-36), the dysfunction subscale of the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS-D), and the sub-item scores of the BFMDRS-M. Safety outcomes included the House-Brackmann (HB) functional grading score and the visual analog scale (VAS) for facial numbness.ResultsAt the final follow-up at 12 months, the BFMDRS-M showed a mean improvement of 70.7% from baseline. Mean scores of the BFMDRS-M sub-motor (including the eyes, mouth, and speech/swallowing) improved by 65.6, 81.00, and 60%, respectively. The median score of the total BFMDRS-D score was 0.70 ± 1.17 compared with 1.86 ± 2.21 at baseline. There were no serious operative complications in this population. The quality of life of the patients significantly improved (P < 0.05).ConclusionBFTC has proven to be effective in relieving the symptoms of Meige syndrome. This novel surgical approach offers a new alternative treatment for patients who have failed to respond to medications, botulinum toxin injections, and deep brain stimulation (DBS).Clinical Trial Registrationhttps://www.chictr.org.cn/bin/project/edit?pid=54567, ChiCTR2000033481.

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