Simultaneous construction of axial and planar chirality by gold/TY-Phos-catalyzed asymmetric hydroarylation

Pei-Chao Zhang; Yin-Lin Li; Jiafeng He; Hai-Hong Wu; Zhiming Li; Junliang Zhang

doi:10.1038/s41467-021-24678-5

Nature Communications (Jul 2021)

Simultaneous construction of axial and planar chirality by gold/TY-Phos-catalyzed asymmetric hydroarylation

Pei-Chao Zhang,
Yin-Lin Li,
Jiafeng He,
Hai-Hong Wu,
Zhiming Li,
Junliang Zhang

Affiliations

Pei-Chao Zhang: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University
Yin-Lin Li: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University
Jiafeng He: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University
Hai-Hong Wu: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University
Zhiming Li: Department of Chemistry, Fudan University
Junliang Zhang: Department of Chemistry, Fudan University

DOI: https://doi.org/10.1038/s41467-021-24678-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 8

Abstract

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The simultaneous construction of two different types of chiralities is challenging. Here, the authors report a cationic gold-catalyzed asymmetric hydroarylation of ortho-alkynylaryl ferrocene derivatives, which enabled the simultaneous construction of axial and planar chirality.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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