Nature Communications (Nov 2019)
Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status
- Paul A Lyons,
- James E Peters,
- Federico Alberici,
- James Liley,
- Richard M. R. Coulson,
- William Astle,
- Chiara Baldini,
- Francesco Bonatti,
- Maria C Cid,
- Heather Elding,
- Giacomo Emmi,
- Jörg Epplen,
- Loïc Guillevin,
- David R. W. Jayne,
- Tao Jiang,
- Iva Gunnarsson,
- Peter Lamprecht,
- Stephen Leslie,
- Mark A. Little,
- Davide Martorana,
- Frank Moosig,
- Thomas Neumann,
- Sophie Ohlsson,
- Stefanie Quickert,
- Giuseppe A. Ramirez,
- Barbara Rewerska,
- Georg Schett,
- Renato A. Sinico,
- Wojciech Szczeklik,
- Vladimir Tesar,
- Damjan Vukcevic,
- The European Vasculitis Genetics Consortium,
- Benjamin Terrier,
- Richard A Watts,
- Augusto Vaglio,
- Julia U Holle,
- Chris Wallace,
- Kenneth G. C. Smith
Affiliations
- Paul A Lyons
- Department of Medicine, University of Cambridge School of Clinical Medicine, University of Cambridge
- James E Peters
- Department of Medicine, University of Cambridge School of Clinical Medicine, University of Cambridge
- Federico Alberici
- Department of Medicine, University of Cambridge School of Clinical Medicine, University of Cambridge
- James Liley
- Department of Medicine, University of Cambridge School of Clinical Medicine, University of Cambridge
- Richard M. R. Coulson
- Department of Medicine, University of Cambridge School of Clinical Medicine, University of Cambridge
- William Astle
- BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort’s Causeway
- Chiara Baldini
- Rheumatology Unit, University of Pisa
- Francesco Bonatti
- Unit of Molecular Genetics, University Hospital of Parma
- Maria C Cid
- Department of Autoimmune Diseases, Hospital Clínic, University of Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CRB-CELLEX
- Heather Elding
- The National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Strangeways Research Laboratory, Wort’s Causeway
- Giacomo Emmi
- Department of Experimental and Clinical Medicine, University of Firenze
- Jörg Epplen
- Human Genetics, Ruhr University Bochum
- Loïc Guillevin
- Service de Médecine Interne, Hôpital Cochin
- David R. W. Jayne
- Department of Medicine, University of Cambridge School of Clinical Medicine, University of Cambridge
- Tao Jiang
- BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort’s Causeway
- Iva Gunnarsson
- Division of Rheumatology, Department of Medicine, Karolinska University Hospital, Karolinska Institute
- Peter Lamprecht
- Department of Rheumatology and Clinical Immunology, University of Lübeck
- Stephen Leslie
- Schools of Mathematics and Statistics, and BioSciences, and Melbourne Integrative Genomics, University of Melbourne
- Mark A. Little
- Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Tallaght Hospital
- Davide Martorana
- Unit of Molecular Genetics, University Hospital of Parma
- Frank Moosig
- Rheumazentrum Schleswig-Holstein Mitte
- Thomas Neumann
- Department of Internal Medicine 3, Jena University Hospital
- Sophie Ohlsson
- Department of Nephrology, Division of Clinical Sciences, Lund University
- Stefanie Quickert
- Department of Internal Medicine 3, Jena University Hospital
- Giuseppe A. Ramirez
- Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Università Vita Salute San Raffaele and IRCCS Ospedale San Raffaele
- Barbara Rewerska
- Jagiellonian University Medical College
- Georg Schett
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nuremberg and Universitatsklinikum Erlangen
- Renato A. Sinico
- Department of Medicine and Surgery, Università degli Studi di Milano–Bicocca (School of Medicine and Surgery)
- Wojciech Szczeklik
- Jagiellonian University Medical College
- Vladimir Tesar
- Department of Nephrology, 1st Faculty of Medicine and General University Hospital, Charles University
- Damjan Vukcevic
- Schools of Mathematics and Statistics, and BioSciences, and Melbourne Integrative Genomics, University of Melbourne
- The European Vasculitis Genetics Consortium
- Benjamin Terrier
- Service de Médecine Interne, Hôpital Cochin
- Richard A Watts
- Department of Rheumatology, Ipswich Hospital
- Augusto Vaglio
- Department of Biomedical Experimental and Clinical Sciences “Mario Serio”, University of Firenze, and Meyer Children’s Hospital
- Julia U Holle
- Rheumazentrum Schleswig-Holstein Mitte
- Chris Wallace
- Department of Medicine, University of Cambridge School of Clinical Medicine, University of Cambridge
- Kenneth G. C. Smith
- Department of Medicine, University of Cambridge School of Clinical Medicine, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-019-12515-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disorder characterised by asthma, eosinophilia and vasculitis. Here, the authors describe a genome-wide association study of EGPA that reveals clinical and genetic differences between subgroups stratified by autoantibody status (ANCA).
