Nature Communications (Jun 2016)
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
- Mitchell J. Machiela,
- Weiyin Zhou,
- Eric Karlins,
- Joshua N. Sampson,
- Neal D. Freedman,
- Qi Yang,
- Belynda Hicks,
- Casey Dagnall,
- Christopher Hautman,
- Kevin B. Jacobs,
- Christian C. Abnet,
- Melinda C. Aldrich,
- Christopher Amos,
- Laufey T. Amundadottir,
- Alan A. Arslan,
- Laura E. Beane-Freeman,
- Sonja I. Berndt,
- Amanda Black,
- William J. Blot,
- Cathryn H. Bock,
- Paige M. Bracci,
- Louise A. Brinton,
- H Bas Bueno-de-Mesquita,
- Laurie Burdett,
- Julie E. Buring,
- Mary A. Butler,
- Federico Canzian,
- Tania Carreón,
- Kari G. Chaffee,
- I-Shou Chang,
- Nilanjan Chatterjee,
- Chu Chen,
- Constance Chen,
- Kexin Chen,
- Charles C. Chung,
- Linda S. Cook,
- Marta Crous Bou,
- Michael Cullen,
- Faith G. Davis,
- Immaculata De Vivo,
- Ti Ding,
- Jennifer Doherty,
- Eric J. Duell,
- Caroline G. Epstein,
- Jin-Hu Fan,
- Jonine D. Figueroa,
- Joseph F. Fraumeni,
- Christine M. Friedenreich,
- Charles S. Fuchs,
- Steven Gallinger,
- Yu-Tang Gao,
- Susan M. Gapstur,
- Montserrat Garcia-Closas,
- Mia M. Gaudet,
- J. Michael Gaziano,
- Graham G. Giles,
- Elizabeth M. Gillanders,
- Edward L. Giovannucci,
- Lynn Goldin,
- Alisa M. Goldstein,
- Christopher A. Haiman,
- Goran Hallmans,
- Susan E. Hankinson,
- Curtis C. Harris,
- Roger Henriksson,
- Elizabeth A. Holly,
- Yun-Chul Hong,
- Robert N. Hoover,
- Chao A. Hsiung,
- Nan Hu,
- Wei Hu,
- David J. Hunter,
- Amy Hutchinson,
- Mazda Jenab,
- Christoffer Johansen,
- Kay-Tee Khaw,
- Hee Nam Kim,
- Yeul Hong Kim,
- Young Tae Kim,
- Alison P. Klein,
- Robert Klein,
- Woon-Puay Koh,
- Laurence N. Kolonel,
- Charles Kooperberg,
- Peter Kraft,
- Vittorio Krogh,
- Robert C. Kurtz,
- Andrea LaCroix,
- Qing Lan,
- Maria Teresa Landi,
- Loic Le Marchand,
- Donghui Li,
- Xiaolin Liang,
- Linda M. Liao,
- Dongxin Lin,
- Jianjun Liu,
- Jolanta Lissowska,
- Lingeng Lu,
- Anthony M. Magliocco,
- Nuria Malats,
- Keitaro Matsuo,
- Lorna H. McNeill,
- Robert R. McWilliams,
- Beatrice S. Melin,
- Lisa Mirabello,
- Lee Moore,
- Sara H. Olson,
- Irene Orlow,
- Jae Yong Park,
- Ana Patiño-Garcia,
- Beata Peplonska,
- Ulrike Peters,
- Gloria M. Petersen,
- Loreall Pooler,
- Jennifer Prescott,
- Ludmila Prokunina-Olsson,
- Mark P. Purdue,
- You-Lin Qiao,
- Preetha Rajaraman,
- Francisco X. Real,
- Elio Riboli,
- Harvey A. Risch,
- Benjamin Rodriguez-Santiago,
- Avima M. Ruder,
- Sharon A. Savage,
- Fredrick Schumacher,
- Ann G. Schwartz,
- Kendra L. Schwartz,
- Adeline Seow,
- Veronica Wendy Setiawan,
- Gianluca Severi,
- Hongbing Shen,
- Xin Sheng,
- Min-Ho Shin,
- Xiao-Ou Shu,
- Debra T. Silverman,
- Margaret R. Spitz,
- Victoria L. Stevens,
- Rachael Stolzenberg-Solomon,
- Daniel Stram,
- Ze-Zhong Tang,
- Philip R. Taylor,
- Lauren R. Teras,
- Geoffrey S. Tobias,
- David Van Den Berg,
- Kala Visvanathan,
- Sholom Wacholder,
- Jiu-Cun Wang,
- Zhaoming Wang,
- Nicolas Wentzensen,
- William Wheeler,
- Emily White,
- John K. Wiencke,
- Brian M. Wolpin,
- Maria Pik Wong,
- Chen Wu,
- Tangchun Wu,
- Xifeng Wu,
- Yi-Long Wu,
- Jay S. Wunder,
- Lucy Xia,
- Hannah P. Yang,
- Pan-Chyr Yang,
- Kai Yu,
- Krista A. Zanetti,
- Anne Zeleniuch-Jacquotte,
- Wei Zheng,
- Baosen Zhou,
- Regina G. Ziegler,
- Luis A. Perez-Jurado,
- Neil E. Caporaso,
- Nathaniel Rothman,
- Margaret Tucker,
- Michael C. Dean,
- Meredith Yeager,
- Stephen J. Chanock
Affiliations
- Mitchell J. Machiela
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Weiyin Zhou
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Eric Karlins
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Joshua N. Sampson
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Neal D. Freedman
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Qi Yang
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Belynda Hicks
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Casey Dagnall
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Christopher Hautman
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Kevin B. Jacobs
- Division of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Leidos Biomedical Research Inc.
- Christian C. Abnet
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Melinda C. Aldrich
- Department of Thoracic Surgery, Vanderbilt University School of Medicine
- Christopher Amos
- Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center
- Laufey T. Amundadottir
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Alan A. Arslan
- Department of Obstetrics and Gynecology, New York University School of Medicine
- Laura E. Beane-Freeman
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Sonja I. Berndt
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Amanda Black
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- William J. Blot
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center
- Cathryn H. Bock
- Karmanos Cancer Institute and Department of Oncology, Wayne State University School of Medicine
- Paige M. Bracci
- Department of Epidemiology and Biostatistics, University of California San Francisco
- Louise A. Brinton
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- H Bas Bueno-de-Mesquita
- Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM)
- Laurie Burdett
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Julie E. Buring
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Mary A. Butler
- National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention
- Federico Canzian
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Tania Carreón
- National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention
- Kari G. Chaffee
- Department of Health Sciences Research, Mayo Clinic
- I-Shou Chang
- National Institute of Cancer Research, National Health Research Institutes
- Nilanjan Chatterjee
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Chu Chen
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Constance Chen
- Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health
- Kexin Chen
- Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital
- Charles C. Chung
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Linda S. Cook
- University of New Mexico
- Marta Crous Bou
- Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health
- Michael Cullen
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Faith G. Davis
- Department of Public Health Sciences, School of Public Health, University of Alberta
- Immaculata De Vivo
- Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health
- Ti Ding
- Shanxi Cancer Hospital
- Jennifer Doherty
- Geisel School of Medicine, Dartmouth College
- Eric J. Duell
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology (ICO-IDIBELL)
- Caroline G. Epstein
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Jin-Hu Fan
- Shanghai Cancer Institute
- Jonine D. Figueroa
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Joseph F. Fraumeni
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Christine M. Friedenreich
- Department of Population Health Research, Cancer Control Alberta, Alberta Health Services
- Charles S. Fuchs
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School
- Steven Gallinger
- Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute
- Yu-Tang Gao
- Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotaong University School of Medicine
- Susan M. Gapstur
- Epidemiology Research Program, American Cancer Society
- Montserrat Garcia-Closas
- Division of Genetics and Epidemiology, and Breakthrough Breast Cancer Centre, Institute for Cancer Research
- Mia M. Gaudet
- Epidemiology Research Program, American Cancer Society
- J. Michael Gaziano
- Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Graham G. Giles
- Cancer Epidemiology Centre, Cancer Council Victoria & Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
- Elizabeth M. Gillanders
- Division of Cancer Control and Population Sciences, National Cancer Institute
- Edward L. Giovannucci
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School
- Lynn Goldin
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Alisa M. Goldstein
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Christopher A. Haiman
- Department of Preventive Medicine, Biostatistics Division, Keck School of Medicine at the University of Southern California
- Goran Hallmans
- Department of Public Health and Clinical Medicine/Nutritional Research, Umeå University
- Susan E. Hankinson
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School
- Curtis C. Harris
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute
- Roger Henriksson
- Department of Radiation Sciences, Oncology, Umeå University
- Elizabeth A. Holly
- Department of Epidemiology and Biostatistics, University of California San Francisco
- Yun-Chul Hong
- Department of Preventive Medicine, Seoul National University College of Medicine
- Robert N. Hoover
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Chao A. Hsiung
- Institute of Population Health Sciences, National Health Research Institutes
- Nan Hu
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Wei Hu
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- David J. Hunter
- Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health
- Amy Hutchinson
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Mazda Jenab
- International Agency for Research on Cancer (IARC-WHO)
- Christoffer Johansen
- Oncology, Finsen Centre
- Kay-Tee Khaw
- School of Clinical Medicine, University of Cambridge
- Hee Nam Kim
- Center for Creative Biomedical Scientists, Chonnam National University
- Yeul Hong Kim
- Department of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital
- Young Tae Kim
- Department of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine
- Alison P. Klein
- Department of Oncology, The Johns Hopkins University School of Medicine
- Robert Klein
- Program in Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center
- Woon-Puay Koh
- Duke-NUS Graduate Medical School
- Laurence N. Kolonel
- Epidemiology Program, University of Hawaii Cancer Center
- Charles Kooperberg
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Peter Kraft
- Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health
- Vittorio Krogh
- Fondazione IRCCS Istituto Nazionale dei Tumori
- Robert C. Kurtz
- Department of Medicine, Memorial Sloan-Kettering Cancer Center
- Andrea LaCroix
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Qing Lan
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Maria Teresa Landi
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Loic Le Marchand
- Epidemiology Program, University of Hawaii Cancer Center
- Donghui Li
- Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center
- Xiaolin Liang
- Memorial Sloan-Kettering Cancer Center
- Linda M. Liao
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Dongxin Lin
- Department of Etiology & Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Jianjun Liu
- Department of Human Genetics, Genome Institute of Singapore
- Jolanta Lissowska
- Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Cancer Center and Institute of Oncology
- Lingeng Lu
- Yale School of Public Health
- Anthony M. Magliocco
- H. Lee Moffitt Cancer Center and Research Institute
- Nuria Malats
- Spanish National Cancer Research Centre (CNIO)
- Keitaro Matsuo
- Division of Molecular Medicine, Aichi Cancer Center Research Institute
- Lorna H. McNeill
- Department of Health Disparities Research, Division of OVP, Cancer Prevention and Population Sciences, and Center for Community-Engaged Translational Research, Duncan Family Institute, The University of Texas MD Anderson Cancer Center
- Robert R. McWilliams
- Department of Oncology, Mayo Clinic
- Beatrice S. Melin
- Department of Radiation Sciences, Oncology, Umeå University
- Lisa Mirabello
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Lee Moore
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Sara H. Olson
- Memorial Sloan-Kettering Cancer Center
- Irene Orlow
- Memorial Sloan-Kettering Cancer Center
- Jae Yong Park
- Lung Cancer Center, Kyungpook National University Medical Center
- Ana Patiño-Garcia
- Department of Pediatrics, University Clinic of Navarra, Universidad de Navarra, IdiSNA, Navarra Institute for Health Research
- Beata Peplonska
- Nofer Institute of Occupational Medicine
- Ulrike Peters
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Gloria M. Petersen
- Department of Health Sciences Research, Mayo Clinic
- Loreall Pooler
- University of Southern California
- Jennifer Prescott
- Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health
- Ludmila Prokunina-Olsson
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Mark P. Purdue
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- You-Lin Qiao
- Department of Epidemiology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences
- Preetha Rajaraman
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Francisco X. Real
- Spanish National Cancer Research Centre (CNIO)
- Elio Riboli
- Division of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Harvey A. Risch
- Yale School of Public Health
- Benjamin Rodriguez-Santiago
- Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra
- Avima M. Ruder
- National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention
- Sharon A. Savage
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Fredrick Schumacher
- Department of Preventive Medicine, Biostatistics Division, Keck School of Medicine at the University of Southern California
- Ann G. Schwartz
- Karmanos Cancer Institute and Department of Oncology, Wayne State University School of Medicine
- Kendra L. Schwartz
- Karmanos Cancer Institute and Department of Family Medicine and Public Health Sciences, Wayne State University School of Medicine
- Adeline Seow
- Saw Swee Hock School of Public Health, National University of Singapore
- Veronica Wendy Setiawan
- Department of Preventive Medicine, Biostatistics Division, Keck School of Medicine at the University of Southern California
- Gianluca Severi
- Cancer Epidemiology Centre, Cancer Council Victoria & Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
- Hongbing Shen
- Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Nanjing Medical University
- Xin Sheng
- University of Southern California
- Min-Ho Shin
- Department of Preventive Medicine, Chonnam National University Medical School
- Xiao-Ou Shu
- Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center
- Debra T. Silverman
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Margaret R. Spitz
- Baylor College of Medicine
- Victoria L. Stevens
- Epidemiology Research Program, American Cancer Society
- Rachael Stolzenberg-Solomon
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Daniel Stram
- Department of Preventive Medicine, Biostatistics Division, Keck School of Medicine at the University of Southern California
- Ze-Zhong Tang
- Shanxi Cancer Hospital
- Philip R. Taylor
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Lauren R. Teras
- Epidemiology Research Program, American Cancer Society
- Geoffrey S. Tobias
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- David Van Den Berg
- Department of Preventive Medicine, Biostatistics Division, Keck School of Medicine at the University of Southern California
- Kala Visvanathan
- Johns Hopkins Bloomberg School of Public Health
- Sholom Wacholder
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Jiu-Cun Wang
- Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University
- Zhaoming Wang
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Nicolas Wentzensen
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- William Wheeler
- Information Management Services Inc.
- Emily White
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- John K. Wiencke
- University of California San Francisco
- Brian M. Wolpin
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School
- Maria Pik Wong
- Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Chen Wu
- Department of Etiology & Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Tangchun Wu
- Institute of Occupational Medicine and Ministry of Education Key Laboratory for Environment and Health, School of Public Health, Huazhong University of Science and Technology
- Xifeng Wu
- Department of Epidemiology, The University of Texas MD Anderson Cancer Center
- Yi-Long Wu
- Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences
- Jay S. Wunder
- Division of Urologic Surgery, Washington University School of Medicine
- Lucy Xia
- University of Southern California
- Hannah P. Yang
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Pan-Chyr Yang
- Department of Internal Medicine, National Taiwan University College of Medicine
- Kai Yu
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Krista A. Zanetti
- Division of Cancer Control and Population Sciences, National Cancer Institute
- Anne Zeleniuch-Jacquotte
- New York University Cancer Institute
- Wei Zheng
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center
- Baosen Zhou
- Department of Epidemiology, School of Public Health, China Medical University
- Regina G. Ziegler
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Luis A. Perez-Jurado
- Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra
- Neil E. Caporaso
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Nathaniel Rothman
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Margaret Tucker
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Michael C. Dean
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Meredith Yeager
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Stephen J. Chanock
- Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)
- DOI
- https://doi.org/10.1038/ncomms11843
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 9
Abstract
It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer risk
