Nature Communications (Nov 2021)
Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction
- Baptiste Lamarthée,
- Armance Marchal,
- Soëli Charbonnier,
- Tifanie Blein,
- Juliette Leon,
- Emmanuel Martin,
- Lucas Rabaux,
- Katrin Vogt,
- Matthias Titeux,
- Marianne Delville,
- Hélène Vinçon,
- Emmanuelle Six,
- Nicolas Pallet,
- David Michonneau,
- Dany Anglicheau,
- Christophe Legendre,
- Jean-Luc Taupin,
- Ivan Nemazanyy,
- Birgit Sawitzki,
- Sylvain Latour,
- Marina Cavazzana,
- Isabelle André,
- Julien Zuber
Affiliations
- Baptiste Lamarthée
- Laboratoire de lymphohématopoïèse humaine, INSERM UMR 1163, IHU IMAGINE
- Armance Marchal
- Laboratoire de lymphohématopoïèse humaine, INSERM UMR 1163, IHU IMAGINE
- Soëli Charbonnier
- Laboratoire de lymphohématopoïèse humaine, INSERM UMR 1163, IHU IMAGINE
- Tifanie Blein
- Laboratoire de lymphohématopoïèse humaine, INSERM UMR 1163, IHU IMAGINE
- Juliette Leon
- Department of Immunology, Harvard Medical School
- Emmanuel Martin
- Lymphocyte activation and susceptibility to EBV, INSERM UMR 1163, IHU IMAGINE
- Lucas Rabaux
- Laboratoire de lymphohématopoïèse humaine, INSERM UMR 1163, IHU IMAGINE
- Katrin Vogt
- Department of Immunology, Charité University Hospital
- Matthias Titeux
- Maladie génétique cutanée, INSERM UMR 1163, IHU IMAGINE
- Marianne Delville
- Laboratoire de lymphohématopoïèse humaine, INSERM UMR 1163, IHU IMAGINE
- Hélène Vinçon
- Laboratoire de lymphohématopoïèse humaine, INSERM UMR 1163, IHU IMAGINE
- Emmanuelle Six
- Laboratoire de lymphohématopoïèse humaine, INSERM UMR 1163, IHU IMAGINE
- Nicolas Pallet
- Université de Paris, INSERM U1138, Centre de Recherche des Cordeliers
- David Michonneau
- Université de Paris
- Dany Anglicheau
- Université de Paris
- Christophe Legendre
- Université de Paris
- Jean-Luc Taupin
- Université de Paris
- Ivan Nemazanyy
- Plateforme de Métabolique, Structure Fédérative de Recherche, Necker, INSERM US24/CNRS UMS
- Birgit Sawitzki
- Department of Immunology, Charité University Hospital
- Sylvain Latour
- Lymphocyte activation and susceptibility to EBV, INSERM UMR 1163, IHU IMAGINE
- Marina Cavazzana
- Laboratoire de lymphohématopoïèse humaine, INSERM UMR 1163, IHU IMAGINE
- Isabelle André
- Laboratoire de lymphohématopoïèse humaine, INSERM UMR 1163, IHU IMAGINE
- Julien Zuber
- Laboratoire de lymphohématopoïèse humaine, INSERM UMR 1163, IHU IMAGINE
- DOI
- https://doi.org/10.1038/s41467-021-26844-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Chimeric antigen receptor engineering in T cells has been shown to be of great potential therapeutic benefit in a range of immune pathologies, although the functionality of such cell therapies can be limited due to tonic signalling and the induction of dysfunction. Here the authors show transient inhibition of mTOR can rescue their 41-BB-CAR-Tregs from tonic signalling-induced dysfunction.
