Serum lipid profile of patients with gallstone disease in rural Western Uttar Pradesh

Abstract

Abstract Introduction Gallstone disease is a common gastrointestinal disorder with varying prevalence across regions. This study explores the demographics and lipid profiles of individuals with cholelithiasis, emphasizing the association between metabolic syndrome and gallstone formation. Methodology A prospective study was conducted, including 100 outpatients with cholelithiasis. Demographic data, lipid profiles, and comorbidities were recorded, and statistical analysis was performed. Results A higher prevalence of gallstones was recorded in the 20–29 age group and among females. Lipid profiles revealed elevated levels of total cholesterol, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), and triglycerides in individuals with metabolic syndrome. High-density lipoprotein (HDL) levels were notably lower in those with metabolic syndrome. Age and gender disparities in metabolic syndrome prevalence were observed, with statistical significance noted in gender-based differences. Serum thyroid-stimulating hormone (TSH) levels did not significantly differ between individuals with and without metabolic syndrome. Conclusion The findings indicated elevated lipid profiles, particularly low HDL, are associated with metabolic syndrome in gallstone patients. Further understanding of these associations can aid in preventive strategies and targeted interventions.

Keywords

• Gallstone disease
• Metabolic syndrome
• Lipid profile
• Thyroid-stimulating hormone