Nature Communications (Aug 2019)
Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis
- Lixue Cao,
- Geyan Wu,
- Jinrong Zhu,
- Zhanyao Tan,
- Dongni Shi,
- Xingui Wu,
- Miaoling Tang,
- Ziwen Li,
- Yameng Hu,
- Shuxia Zhang,
- Ruyuan Yu,
- Shuang Mo,
- Jueheng Wu,
- Erwei Song,
- Mengfeng Li,
- Libing Song,
- Jun Li
Affiliations
- Lixue Cao
- Key Laboratory of Liver Disease of Guangdong Province, The Third Affiliated Hospital, Sun Yat-sen University
- Geyan Wu
- Key Laboratory of Liver Disease of Guangdong Province, The Third Affiliated Hospital, Sun Yat-sen University
- Jinrong Zhu
- Key Laboratory of Liver Disease of Guangdong Province, The Third Affiliated Hospital, Sun Yat-sen University
- Zhanyao Tan
- Department of Biochemistry, Zhongshan school of medicine, Sun Yat-sen University
- Dongni Shi
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
- Xingui Wu
- Department of Biochemistry, Zhongshan school of medicine, Sun Yat-sen University
- Miaoling Tang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
- Ziwen Li
- Department of Biochemistry, Zhongshan school of medicine, Sun Yat-sen University
- Yameng Hu
- Department of Biochemistry, Zhongshan school of medicine, Sun Yat-sen University
- Shuxia Zhang
- Department of Biochemistry, Zhongshan school of medicine, Sun Yat-sen University
- Ruyuan Yu
- Department of Biochemistry, Zhongshan school of medicine, Sun Yat-sen University
- Shuang Mo
- Department of Biochemistry, Zhongshan school of medicine, Sun Yat-sen University
- Jueheng Wu
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University
- Erwei Song
- Department of Breast Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Mengfeng Li
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University
- Libing Song
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
- Jun Li
- Key Laboratory of Liver Disease of Guangdong Province, The Third Affiliated Hospital, Sun Yat-sen University
- DOI
- https://doi.org/10.1038/s41467-019-11696-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
It is known that genotoxic stress induces high levels of ROS and deplete cellular glutathione stores. Here, Cao et al. uncover a β-catenin-dependent TCF/LEF-independent mechanism that promotes histone-mediated transcriptional activation of glutathione synthesis.
