Nature Communications (Apr 2020)
Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia
- Matthew Halvorsen,
- Ruth Huh,
- Nikolay Oskolkov,
- Jia Wen,
- Sergiu Netotea,
- Paola Giusti-Rodriguez,
- Robert Karlsson,
- Julien Bryois,
- Björn Nystedt,
- Adam Ameur,
- Anna K. Kähler,
- NaEshia Ancalade,
- Martilias Farrell,
- James J. Crowley,
- Yun Li,
- Patrik K. E. Magnusson,
- Ulf Gyllensten,
- Christina M. Hultman,
- Patrick F. Sullivan,
- Jin P. Szatkiewicz
Affiliations
- Matthew Halvorsen
- Department of Genetics, University of North Carolina
- Ruth Huh
- Department of Biostatistics, University of North Carolina
- Nikolay Oskolkov
- Department of Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Lund University
- Jia Wen
- Department of Genetics, University of North Carolina
- Sergiu Netotea
- Department of Biology and Biological Engineering, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Chalmers University of Technology
- Paola Giusti-Rodriguez
- Department of Genetics, University of North Carolina
- Robert Karlsson
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Julien Bryois
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Björn Nystedt
- Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University
- Adam Ameur
- Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University
- Anna K. Kähler
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- NaEshia Ancalade
- Department of Genetics, University of North Carolina
- Martilias Farrell
- Department of Genetics, University of North Carolina
- James J. Crowley
- Department of Genetics, University of North Carolina
- Yun Li
- Department of Genetics, University of North Carolina
- Patrik K. E. Magnusson
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Ulf Gyllensten
- Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University
- Christina M. Hultman
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Patrick F. Sullivan
- Department of Genetics, University of North Carolina
- Jin P. Szatkiewicz
- Department of Genetics, University of North Carolina
- DOI
- https://doi.org/10.1038/s41467-020-15707-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Common variants identified by large-scale genomewide association studies cannot account fully account for the heritability of schizophrenia (SCZ). Here, the authors report high-coverage whole-genome sequencing of 1162 SCZ cases and 936 controls and explore the contribution of different types of variants to SCZ.
