Communications Biology (Sep 2021)

Single-cell profiling defines the prognostic benefit of CD39high tissue resident memory CD8+ T cells in luminal-like breast cancer

  • Agnese Losurdo,
  • Caterina Scirgolea,
  • Giorgia Alvisi,
  • Jolanda Brummelman,
  • Valentina Errico,
  • Luca Di Tommaso,
  • Karolina Pilipow,
  • Federico Simone Colombo,
  • Bethania Fernandes,
  • Clelia Peano,
  • Alberto Testori,
  • Corrado Tinterri,
  • Massimo Roncalli,
  • Armando Santoro,
  • Emilia Maria Cristina Mazza,
  • Enrico Lugli

DOI
https://doi.org/10.1038/s42003-021-02595-z
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 11

Abstract

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Losurdo et al analyze breast cancer-infiltrating T cells by single-cell technologies . The find that the extent of infiltration of a small subset of tissue-resident memory CD8+ T cells identify patients with improved survival, highlighting the importance of the specific T cell immune microenvironment.