GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl−-sensitive WNK1 kinase

Martin Heubl; Jinwei Zhang; Jessica C. Pressey; Sana Al Awabdh; Marianne Renner; Ferran Gomez-Castro; Imane Moutkine; Emmanuel Eugène; Marion Russeau; Kristopher T. Kahle; Jean Christophe Poncer; Sabine Lévi

doi:10.1038/s41467-017-01749-0

Nature Communications (Nov 2017)

GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl−-sensitive WNK1 kinase

Martin Heubl,
Jinwei Zhang,
Jessica C. Pressey,
Sana Al Awabdh,
Marianne Renner,
Ferran Gomez-Castro,
Imane Moutkine,
Emmanuel Eugène,
Marion Russeau,
Kristopher T. Kahle,
Jean Christophe Poncer,
Sabine Lévi

Affiliations

Martin Heubl: Inserm UMR-S 839
Jinwei Zhang: MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee
Jessica C. Pressey: Inserm UMR-S 839
Sana Al Awabdh: Inserm UMR-S 839
Marianne Renner: Inserm UMR-S 839
Ferran Gomez-Castro: Inserm UMR-S 839
Imane Moutkine: Inserm UMR-S 839
Emmanuel Eugène: Inserm UMR-S 839
Marion Russeau: Inserm UMR-S 839
Kristopher T. Kahle: Departments of Neurosurgery, Pediatrics, and Cellular & Molecular Physiology, NIH-Yale Centers for Mendelian Genomics, Yale School of Medicine
Jean Christophe Poncer: Inserm UMR-S 839
Sabine Lévi: Inserm UMR-S 839

DOI: https://doi.org/10.1038/s41467-017-01749-0
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 17

Abstract

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GABAergic transmission regulates the K+-Cl− co-transporter KCC2. Here the authors demonstrate that inhibitory transmission, via GABAA receptor and WNK signaling, regulates KCC2 expression in the membrane of hippocampal neurons.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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