HYDROBONDED NONWOVEN SILVER-CONTAINING MATERIAL IN TREATMENT OF ASEPTIC WOUNDS

Abstract

Background. The urgent problem of surgery is the search for new and promising bandaging materials for the treatment of wounds. One of the variants may be a hydrobonded nonwoven material with silver nanoparticles, obtained by the laser ablation method. Aim of the research. To study the effect of a hydrobonded nonwoven material, containing silver nanoparticles of various sizes, on the healing of an experimental aseptic cutaneous wound and the parameters of complete and biochemical blood tests as well as to determine the possible toxicity of silver nanoparticles on the liver, kidneys and myocardium. Material and methods. Silver nanoparticles were obtained by the laser ablation method in a liquid. The wound healing effect was evaluated on a model of an aseptic skin wound in laboratory white rats. After the healing of the wound blood was taken for complete and biochemical tests. The toxic effect of a hydrobonded bandaging material on the liver, kidneys and myocardium was assessed pathomorphologically and by changes in the biochemical blood test. Results. The obtained data demonstrated acceleration of the healing of the experimental aseptic skin wound with the use of silver nanoparticles by 9.2-15.6 % and the absence of toxic effects of silver nanoparticles on the liver, kidneys and myocardium, as well as significant changes in the indices of complete and biochemical blood tests. Conclusions. Hydrobonded nonwoven material with silver nanoparticles accelerates the healing of an aseptic skin wound without causing toxic effects on the liver, kidneys and myocardium. It can be used in clinical practice after further studying

Keywords

• wound coatings
• experimental aseptic wound
• silver nanoparticles