The pilot study of the basic pharmacokinetic properties of pyrrolylcarnosine — the new pyrrolic derivative of dipeptide carnosine

Abstract

The experimental study of the pharmacokinetic characteristics of a new pyrrole derivative of carnosine, pyrrolylcarnosine, was carried out. Based on the results of the experiment, the basic pharmacokinetic parameters of the drug are expected. The tissues and organs bioavailability was studied. The tropism of pyrrolylcarnosine to the organs of elimination and the ability of pyrrolylcarnosine to penetrate into the heart muscle tissue were shown.

Keywords

• pyrrole
• carnosine
• pyrrolylcarnosine
• pharmacokinetics
• tissue availability
• distribution
• chromatography
• mass-spectrometry