Nature Communications (Apr 2016)

Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells

  • Hiroyuki Hosokawa,
  • Tomoaki Tanaka,
  • Yusuke Endo,
  • Miki Kato,
  • Kenta Shinoda,
  • Akane Suzuki,
  • Shinichiro Motohashi,
  • Masaki Matsumoto,
  • Keiichi I. Nakayama,
  • Toshinori Nakayama

DOI
https://doi.org/10.1038/ncomms11289
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

Read online

Although IFNγ is a Th1 signature cytokine and is repressed in Th2 cells, it is reactivated in a subset of memory Th2 cells. Here the authors show that Hdac2 is released from Gata3 by Akt-mediated phosphorylation, leading to transcriptional derepression of Tbx21 and IFNγin these cells.