Micromachines (Nov 2012)

Approaches and Challenges of Engineering Implantable Microelectromechanical Systems (MEMS) Drug Delivery Systems for in Vitro and in Vivo Applications

  • Ken-Tye Yong,
  • Indrajit Roy,
  • Rui Hu,
  • Peiyi Song,
  • Danny Jian Hang Tng

DOI
https://doi.org/10.3390/mi3040615
Journal volume & issue
Vol. 3, no. 4
pp. 615 – 631

Abstract

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Despite the advancements made in drug delivery systems over the years, many challenges remain in drug delivery systems for treating chronic diseases at the personalized medicine level. The current urgent need is to develop novel strategies for targeted therapy of chronic diseases. Due to their unique properties, microelectromechanical systems (MEMS) technology has been recently engineered as implantable drug delivery systems for disease therapy. This review examines the challenges faced in implementing implantable MEMS drug delivery systems in vivo and the solutions available to overcome these challenges.

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